ADCO-CEFACLOR BD FORTE 375 Granules for Suspension
Country: South Africa
Language: English
Source: South African Health Products Regulatory Authority (SAHPRA)
Patient Information leaflet
(PIL)
26-04-2024
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Patient Information leaflet
ADCO-CEFACLOR BD 187 Granules for Suspension
ADCO-CEFACLOR BD FORTE 375 Granules for Suspension
SCHEDULING STATUS:
S4
PROPRIETARY NAME
(and dosage form):
ADCO-CEFACLOR BD 187 Granules for Suspension
ADCO-CEFACLOR BD FORTE 375 Granules for Suspension
COMPOSITION:
After mixing, each 5 mL
ADCO-CEFACLOR BD 187 suspension contains 187 mg
cefaclor
.
After mixing, each 5 mL
ADCO-CEFACLOR BD FORTE 375 suspension contains 375 mg cefaclor.
Cefaclor is chemically designated as 3-chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid monohydrate.
PHARMACOLOGICAL CLASSIFICATION:
A 20.1.1 Broad and Medium Spectrum Antibiotics
PHARMACOLOGICAL ACTION:
Cefaclor is a semi-synthetic cephalosporin antibiotic with a broad spectrum of bactericidal activity against certain Gram-
positive and Gram-negative micro-organisms.
Human pharmacology: Cefaclor is absorbed after oral administration whether taken with food or while fasting.
Approximately 60% of the agent is excreted unchanged in the urine within 8 hours. Cefaclor is not appreciably
metabolised. The presence of food in the gastro-intestinal tract delays absorption and lowers peak serum levels, but does
not alter the total amount of cefaclor absorbed.
Microbiology: In vitro tests demonstrate that the bactericidal action of the cephalosporins results from inhibition of cell-
wall synthesis.
Cefaclor is active against the following organisms in vitro:
Strains of staphylococci, including coagulase-positive, coagulase-negative and penicillinase-producing strains, are
moderately sensitive.
Streptococcus pyogenes (group A beta-haemolytic streptococci).
Streptococcus pneumoniae.
Escherichia coli.
Proteus mirabilis.
Klebsiella sp.
Haemophilus influenzae, including ampicillin-resistant strains.
Moraxella (Branhamella) catarrhalis.
Note: Cefaclor has no activity against Pseudomonas species,
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