Country: South Africa
Language: English
Source: South African Health Products Regulatory Authority (SAHPRA)
Adcock
ADCO-CIMETIDINE 200 mg TABLETS ADCO-CIMETIDINE 400 mg TABLETS ADCO-CIMETIDINE 800 mg TABLETS SCHEDULING STATUS: S3 PROPRIETARY NAME: (and dosage form) ADCO-CIMETIDINE 200 mg TABLETS ADCO-CIMETIDINE 400 mg TABLETS ADCO-CIMETIDINE 800 mg TABLETS COMPOSITION: Each ADCO-CIMETIDINE 200 mg Tablet (green, round tablet) contains 200 mg cimetidine . Each ADCO-CIMETIDINE 400 mg Tablet (green, oblong tablet) contains 400 mg cimetidine. Each ADCO-CIMETIDINE 800 mg Tablet (green, elliptical tablet) contains 800 mg cimetidine. PHARMACOLOGICAL CLASSIFICATION: A 11.4.3 Antacids : Other. PHARMACOLOGICAL ACTION: ADCO-CIMETIDINE inhibits basal (fasting) and nocturnal gastric acid secretion and reduces pepsin output by competitive inhibition of the action of histamine at the histamine H 2 -receptors of the parietal cells. ADCO-CIMETIDINE also inhibits gastric secretion elicited by muscarinic agonists or by gastrin, although this effect is not always complete. It reduces both the volume of gastric juice secreted and its hydrogen ion concentration. After oral administration, peak plasma concentrations are obtained in about 1 to 2 hours. The bioavailability of cimetidine following oral administration is about 60% due to first pass metabolism. ADCO-CIMETIDINE is eliminated primarily by the kidneys. INDICATIONS: Duodenal ulcer Gastric ulcer Reflux oesophagitis Upper gastrointestinal bleeding Hypersecretory states associated with systemic mastocytosis or basophilic leukemia with hyperhistaminemia or Zollinger - Ellison syndrome. CONTRA-INDICATIONS: Sensitivity to cimetidine or related agents. Should not be administered to pregnant or lactating patients. DOSAGE AND DIRECTIONS FOR USE: Since ADCO-CIMETIDINE may not always give immediate symptomatic relief, antacids should be made available to patients as needed for relief of pa Read the complete document