Country: South Africa
Language: English
Source: South African Health Products Regulatory Authority (SAHPRA)
Lennon
AMILORETIC® TABLETS AMILORETIC® H.S. TABLETS SCHEDULING STATUS: S3 PROPRIETARY NAME (and dosage form): AMILORETIC ® TABLETS AMILORETIC ® H.S. TABLETS COMPOSITION: Each Amiloretic tablet contains: Amiloride hydrochloride 5 mg Hydrochlorothiazide 50 mg Each Amiloretic H.S. tablet contains Amiloride hydrochloride 2,5 mg Hydrochlorothiazide 25 mg PHARMACOLOGICAL CLASSIFICATION: A 18.1 Diuretics. PHARMACOLOGICAL ACTION: Hydrochlorothiazide and amiloride are both oral diuretics which act by reducing reabsorption of electrolytes from the renal tubules thereby increasing the excretion of sodium and chloride ions and consequently of water. Hydrochlorothiazide also increases the excretion of potassium ions while amiloride has the opposite effect and has been found to diminish the kaluretic effects of other diuretics i.e. hydrochlorothiazide in this combination. Hydrochlorothiazide slightly increases the bicarbonate excretion without appreciable alteration to the acid-base balance or the pH of the urine. It has an anti-hypertensive effect and enhances the action of other hypotensive agents. INDICATIONS: Oedema of cardiac decompensation or associated with hepatic cirrhosis and corticosteroid therapy. Essential hypertension. CONTRA-INDICATIONS: Patients with a hypersensitivity towards either hydrochlorothiazide or amiloride. Severe renal and/or hepatic insufficiency. Patients with hyperkalaemia. Safety in pregnancy, lactation and childhood has not been established. Chlorothiazide crosses the placenta which may cause neonatal jaundice, thrombocytopenia, and electrolyte imbalances. Chlorothiazide is excreted in the breast milk. Treatment with thiazide diuretics can inhibit lactation. The safe use of hydrochlorothiazide is contentious in patients with porphyria. DOSAGE AND Read the complete document