Country: South Africa
Language: English
Source: South African Health Products Regulatory Authority (SAHPRA)
Lennon
BENZHEXOL TABLETS SCHEDULING STATUS: S5 PROPRIETARY NAME (and dosage form): BENZHEXOL TABLETS COMPOSITION: Each tablet contains 2 mg Benzhexol Hydrochloride. PHARMACOLOGICAL CLASSIFICATION: A 5.4.1 Anti-Parkinsonism preparations. PHARMACOLOGICAL ACTION: Benzhexol hydrochloride resembles atropine in its peripheral actions on autonomic effector cells, having an inhibitory effect on the parasympathetic nervous system. It is one half as active as atropine on smooth muscle and one third as active as a mydriatic. It possesses about one tenth the potency of atropine on salivary glands and cardiac-vagal mechanisms. On the C.N.S., the actions of benzhexol likewise resembles those of atropine. In animals, it abolishes tremor induced by nicotine and tremorine as does atropine. Benzhexol does not selectively depress polysynaptic pathways. Present evidence suggests that benzhexol acts by blocking acetylcholine at certain cerebral synaptic sites. INDICATIONS: Benzhexol is used for the symptomatic control of all forms of Parkinsonism, including the postencephalitic arteriosclerotic, and idiopathic types. It favourably influences rigidity and akinesia in the majority of patients. Tremor is generally improved also, but in some instances of severe rigidity, the tremor may be accentuated when the rigidity is diminished. Benzhexol favourably effects mood and reduces salivation. CONTRA-INDICATIONS: Benzhexol hydrochloride should not be given to patients with closed-angle glaucoma or to patients with a narrow angle between the iris and the cornea since its use may increase the intra-ocular pressure. The drug is contra-indicated in patients suffering from a paralytic ileus. DOSAGE AND DIRECTIONS FOR USE: Dosage should be individualised. The initial dose should be low and then increased gradually especially in e Read the complete document