Country: South Africa
Language: English
Source: South African Health Products Regulatory Authority (SAHPRA)
Lennon
CALCIFEROL OILY SOLUTION - LENNON SCHEDULING STATUS: S3 PROPRIETARY NAME (and dosage form): CALCIFEROL OILY SOLUTION - LENNON COMPOSITION: Each mL of oily solution contains 0,125 mg of Calciferol . (equivalent to: 5 000 IU of Vitamin D ) PHARMACOLOGICAL CLASSIFICATION: A 22.1.4 Vitamins - Other PHARMACOLOGICAL ACTION: Vitamin D is best characterised as a positive regulator of calcium homeostasis. Phosphate metabolism is affected by the vitamin in a manner parallel to that of calcium. The mechanism by which Vitamin D acts to maintain normal concentrations of calcium and phosphate in plasma are to facilitate their absorption by the small intestine, to interact with parathyroid hormone to enhance their mobilization from bone, and to decrease their excretion by the kidney. Vitamin D is essential for normal calcification of bone. Normal bone formation occurs when calcium and phosphate concentrations in the plasma are adequate. Vitamin D substances are well absorbed from the gastro intestinal tract. The presence of bile is essential for adequate intestinal absorption. Absorbed Vitamin D circulates in the blood in association with Vitamin D - binding protein. The vitamin disappears from the plasma with a half life of 19 to 25 hours but is stored in fat depots for prolonged periods. The primary route of excretion of Vitamin D is the bile. Vitamin D and its metabolites undergo extensive enterohepatic recirculation. INDICATIONS: For the treatment of nutritional rickets, the treatment of metabolic rickets and osteomalacia, and the treatment of hypoparathyroidism. CONTRA INDICATIONS: Hypersensitivity to any of the ingredients. Vitamin D should not be administered to patients with hypercalcaemia. It is advised that, if possible, women receiving pharmacological doses of Vitamin D do no Read the complete document