Country: South Africa
Language: English
Source: South African Health Products Regulatory Authority (SAHPRA)
Lennon
ARTHREXIN®-25 and ARTHREXIN®-50 CAPSULES SCHEDULING STATUS: S2 – The emergency treatment of acute gout attacks. S3 – Indomethacin is used to relieve the painful symptoms of ankylosing spondylitis and osteoarthritis and to relieve the pain and swelling in gout, rheumatoid arthritis, and acute musculoskeletal disorders. It has also been used to reduce symptoms in some febrile conditions. PROPRIETARY NAME (and dosage form): ARTHREXIN ® -25 and ARTHREXIN ® -50 CAPSULES COMPOSITION: Capsules containing 25 mg and 50 mg Indomethacin . PHARMACOLOGICAL CLASSIFICATION: A 3.1 Antirheumatics - Anti-inflammatory agents. PHARMACOLOGICAL ACTION: Indomethacin has analgesic, anti-inflammatory and antipyretic properties. Like the salicylates and related anti-inflammatory agents, indomethacin, inhibits the biosynthesis of prostaglandins; this action may be the basis of its anti-inflammatory and antipyretic properties and certain of its other effects. It inhibits motility of polymorphonuclear leucocytes and like salicylates, it uncouples oxidative phosphorylation in supratherapeutic concentrations and depresses the biosynthesis of mucopolysaccharides. Indomethacin is readily absorbed from the gastro-intestinal tract with peak plasma concentrations reached about 2 hours after a dose. The absorption of indomethacin may be slowed by food or aluminium or magnesium containing antacids. About 99% of indomethacin is bound to plasma proteins and indomethacin is distributed into synovial fluid, the central nervous system and the placenta. Low concentrations can be detected in breast milk. INDICATIONS: S2 The emergency treatment of acute gout attacks. S3 Indomethacin is used to relieve the painful symptoms of ankylosing spondylitis and osteoarthritis, and to relieve the pain and swelling in gout, rheumatoid arthritis, Read the complete document