Country: South Africa
Language: English
Source: South African Health Products Regulatory Authority (SAHPRA)
Schering
LOGYNON ED TABLETS SCHEDULING STATUS: S3 PROPRIETARY NAME (and dosage form): LOGYNON ED TABLETS Three-step preparation for oral contraception COMPOSITION The 28-day pack (Every-Day pack) contains 21 hormonal tablets, 6 tablets each with levonorgestrel (d-13-ethyl- 17alpha-ethinyl-17beta-hydroxy-4-gonen-3-one) 0,05 mg and ethinylestradiol (17alpha-ethinyl-estra-1,3,5(10)-triene- 3,17beta-diol) 0,03 mg, plus 5 tablets each with levonorgestrel 0,075 mg and ethinylestradiol 0,04 mg, plus 10 tablets each with levonorgestrel 0,125 mg and ethinylestradiol 0,03 mg, plus 7 non-hormonal tablets. PHARMACOLOGICAL CLASSIFICATION A. 21.8.2 Progesterones with estrogens. PHARMACOLOGICAL ACTION Logynon ED is a three-step preparation for oral contraception, the reliability of which is equal to that of the classical single-phase combined preparations. The three-step dosage scheme conforms with the physiological pattern of the normal cycle, and the total steroid dose is lower in comparison with other currently available combined oral contraceptives. The estrogen/progestogen ratio varies during the cycle, the dosage being administered as a 6-day/5-day/10-day regimen in order to ensure good cycle control and to bring about distinct cyclical changes at the level of the endometrium and the vaginal epithelium. At the same time, however, ovulation is inhibited, and the cervical mucus remains impenetrable, thus providing reliable contraceptive protection. When taken according to instructions, a menstruation-like bleeding is induced at regular intervals of approximately 28 days. INDICATIONS Oral contraception and the recognised gynaecological indications for such estrogen-progestogen combinations. CONTRA-INDICATIONS Pregnancy, severe disturbances of liver function, jaundice or persistent itching during a previous pregnancy, Dubin- J Read the complete document