Country: South Africa
Language: English
Source: South African Health Products Regulatory Authority (SAHPRA)
Lennon
PREDNISONE TABLETS SCHEDULING STATUS: S4 PROPRIETARY NAME (and dosage form): PREDNISONE TABLETS COMPOSITION: Each tablet contains 5 mg prednisone . PHARMACOLOGICAL CLASSIFICATION: A 21.5.1 Corticosteroids and analogues. PHARMACOLOGICAL ACTION: Prednisone is a synthetic glucocorticoid with 5 times the potency mg for mg as cortisone acetate but in equivalent doses causes less sodium and fluid retention although more gastric symptoms. INDICATIONS: Prednisone is indicated in all conditions where corticosteroid therapy is likely to be of benefit. These include acute haemolytic disorders, allergic disorders, asthma, leukaemia, thrombocytopenic purpura, coeliac disease, insulin resistance in diabetes mellitus, immunosuppression, liver disorders and ulcerative colitis. CONTRA-INDICATIONS: Peptic ulcer, osteoporosis, psychoses or severe psycho-neuroses. They should be used with great caution in the presence of congestive heart failure, in patients with diabetes mellitus, infectious diseases, chronic renal failure, uraemia and in elderly persons. Tuberculosis active or possibly latent is a contra-indication unless adequate amounts of suitable anti- tubercular drugs are simultaneously administered. Simultaneous administration of barbiturates or phenytoin may reduce the effectiveness of prednisone by increasing its metabolism and the action of anticoagulants may be modified. In many cases of severe illnesses, where prednisone may be lifesaving, they may be administered notwithstanding the above contra-indications –due caution and observation being exercised by the physician. It should be noted that prednisone has less tendency than many corticosteroids to cause fluid retention and mineral imbalance but it has a somewhat higher incidence of gastric symptoms. DOSAGE AND DIRECTIONS FOR USE: This primarily depends Read the complete document