Country: Tajwan
Lingwa: Ċiniż
Sors: 衛生福利部食品藥物管理署 (Ministry of Health and Welfare, Food And Drug Administration)
LENOGRASTIM (GENETICAL RECOMBINATION)
台灣中外製藥股份有限公司 台北市松山區敦化北路260號3樓 (23060795)
L03AA10
凍晶乾燥注射劑
主成分 () ; LENOGRASTIM (GENETICAL RECOMBINATION) (9200035800) MCG
小瓶;;盒裝;;安瓿附溶液
菌 疫
限由醫師使用
Nipro Pharma Corporation Ise Plant 647-240, Ureshinotengeji-cho, Matsusaka-shi, Mie 515-2302, Japan JP
lenograstim
1.促進造血幹細胞移植時的嗜中性白血球數的增加。2.癌症化學療法所引起之嗜中性白血球缺乏症。3.伴隨著骨髓發育不良症候群的嗜中性白血球減少症。4.先天性、特異性嗜中性白血球缺乏症。5.動員造血幹細胞至週邊血液中。
註銷日期: 2020/09/01; 註銷理由: 自請註銷; 有效日期: 2023/04/22; 英文品名: GRANOCYTE 50
已註銷
2003-02-12
1 2 • 1 • pH 1 1 GRANOCYTE 50 LENOGRASTIM 50 µg L-arginine L-phenylalanine L-methionine Polysorbate 20 D-mannitol 6.0 ~ 7.5 1 100 100 µg 6.0 ~ 7.5 1 250 250 µg 6.0 ~ 7.5 1 ~ 2 1 JP 1 1 • • • • • • 5 µg/kg 2 10 µg/kg 50,000/ mm 3 75,000/mm 3 Granocyte 10 µg/kg 2 4~6 Granocyte 10 µg/ kg 2 4~6 5 µg/kg 5,000/mm 3 2. 1 1 10 20 40 µg / *** 10 20 40 µg / *** 20 µg / *** *** 2~10 µg/kg 1. 2 3,4 5,6 7-9 2. 10 3. 11,12 13 14-16 17-20 21 22 23 4. 24 25 1. 1 28 2 29,30 31 3 32 33 1 2 1 P. AERUGINOSA 7 32 CPA mg/kg i.p. µg/kg s.c. cfu / 10 4 10 5 10 6 10 7 0 0 5/5 5/5 5/5 0/5 200 0 3/5 0/5 NT NT 200 1 5/5 2/5 NT NT 200 10 5/5 4/5 1/5 NT 200 100 5/5 5/5 2/5 NT 2 C. ALBICANS 33 20 Takeshita, A. et al.: Int J Hematol., 71:136 2000 21 7 10 :1123 1994 22 Biotherapy, 13 6 :711 1999 23 Biotherapy, 7 12 :1709 1993 24 Biotherapy, 4 10 :1644 1990 25 32 7 :743 1991 26 Virus 24 5 :399 1996 27 30 1 :30 1995 28 1999 29 18 S-9 :S2487 1990 30 18 S-9 :S2535 1990 31 18 S-9 :S2469 1990 32 Matsumoto, M. et al.: Microbiol. Immunol., 34 9 :765 1990 33 Matsumoto, M. et al.: J. Antimicrob. Chemother., 28:447 1991 34 1990 35 1995 36 Kubota, N. et al.: J. Biochem., 107:486 1990 37 Oheda, M. et al.: J. Biochem., 103:544 1988 38 1 1 :63 1990 39 1989 260 3 TEL 02 2715-2000 Utsunomiya Plant of Chugai Pharma Manufacturing Co., Ltd. P 16-3 Kiyohara Kogyodanchi, Utsunomiya-city, Tochigi, Japan O 5-1 Ukima 5-Chome, Kita-Ku, Tokyo, Japan N ipro Pharma Corporation Ise Plant. 647-240, Ureshinotengeji-cho, Matsusaka-shi, Mie 515- 2302, Japan. 260 3 TEL 02 2715-2000 JPI Jun 2018 JPI version 24 CPA mg/ kg i.p. µg/kg s.c. AMPH-B mg/kg i.v. cfu / 1 2 3 200 0 0 5.110 6 0/8 0/8 0/8 200 0 0.5 5.110 6 10/10 9/10 0/10 200 100 0.5 5.110 6 10/10 10/10 10/10 CPA Cyclophosphamide AMPH-B Amphotericin B 4 34 5 in vitro 35 in vivo 35 2. 1 G-CSF 36,37 38 2 - CFU- GM BFU-E, CFU-E CFU-Meg in vitro 39 Lenograstim genetical recombination JAN 20,000 174 mRNA cDNA 30 50 µg 100 100 µg 100 250 µg 100 1 JP 1 26 11 :1660 1989 2 Linch, D.C. et al.: Br. Haema Aqra d-dokument sħiħ