KHC TRIMETHOMIX 40080MGG PREMIX POWDER

Country: Malaysia

Language: English

Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Active ingredient:

SULFADIMIDINE SODIUM/SULFAMETHAZINE SODIUM; TRIMETHOPRIM

Available from:

KHENG HONG CHAN FARMING SDN BHD

INN (International Name):

SULFADIMIDINE SODIUM/SULFAMETHAZINE SODIUM; TRIMETHOPRIM

Units in package:

1000 gm

Manufactured by:

Thye Pharma Sdn. Bhd

Summary of Product characteristics

Veterinary Package Insert
KHC
TRIMETHOMIX
400/80MG/G
PREMIX POWDER (40% Sulfadimidine &
8% Trimethoprim)
PRODUCT DESCRIPTION
White
or
almost
white
colour
powder,
which
contains 400mg of sulfadimidine (as sulfamidine
sodium 432mg) and 80mg of Trimethoprim in 1g of
product.
PHARMACODYNAMICS & PHARMACOKINETICS
_Pharmacodynamics: _
Sulfadimidine:
Bacteriostatic.
Sulfonamides
interfere
with
the
biosynthesis
of
folic
acid
in
bacterial
cells;
they
compete
with
para-
aminobenzoic acid (PABA) for incorporation in the
folic acid molecule. By replacing the PABA molecule
and preventing the folic acid formation required for
DNA
synthesis,
the
sulfonamides
prevent
multiplication of the bacterial cell. Only organisms
that synthesize their own folic acid are susceptible;
mammalian
cells
use
preformed
folic
acid
and,
therefore, are not susceptible. Cells that produce
excess PABA or environments with PABA, such as
necrotic
tissues,
allow
for
resistance
by
competition with the sulfonamide.
Alone, sulfonamides are bacteriostatic agents and
trimethoprim
is
bactericidal,
but
when
used
in
combination,
the
potentiated
sulfas
are
bactericidal. Potentiated sulfas sequentially inhibit
enzymes
in
the
folic
acid
pathway,
inhibiting
bacterial thymidine synthesis.
_Pharmacokinetics: _
_Sulfadimidine _
_Absorption _
Most sulfonamides are well absorbed orally with
the exception of the enteric sulfonamides, such as
sulfaquinoxaline,
which
are
minimally
absorbed.
Delays in absorption may occur in adult ruminants
or when sulfonamides are administered with food
to monogastric animals.
_Distribution _
Sulfonamides are widely distributed throughout the
body. They cross the placenta, and a few penetrate
into the cerebrospinal fluid. Sulfonamides may be
distributed into milk; however, they vary greatly in
their
ability
to
do
so.
The
process
depends
on
several factors, including protein binding and pKa
values.
_Protein Binding _
Binding
can
vary
depending
on
serum
concentration and other factors.
_Biotransformation _
Sulfonamides are primarily metabolize