Enahexal® 20mg Tablet

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

ENALAPRIL MALEATE

Boleh didapati daripada:

IDAMAN PHARMA SDN. BHD.

INN (Nama Antarabangsa):

ENALAPRIL MALEATE

Unit dalam pakej:

30Tablet Tablets; 50Tablet Tablets; 100Tablet Tablets

Dikeluarkan oleh:

Ilsan Ilac ve Hammaddeleri San. Ve Tic.A.S.,

Risalah maklumat

ENAHEXAL® TABLET _CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
_Enalapril maleate _
ENAHEXAL® 5MG TABLET
ENAHEXAL® 10MG TABLET
ENAHEXAL® 20MG TABLET
_The products Enahexal® 5mg Tablet, _
_Enahexal® 10mg Tablet and _
_Enahexal® 20mg Tablet are referred _
_to as Enahexal throughout this leaflet. _
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Enahexal. It does not
contain all the available information.
It does not take the place of talking to
your doctor or pharmacist. Please read
this entire leaflet carefully before you
start to take your medicine. This
medicine is for you. Never give it to
other people even if their condition
appears to be the same as yours. If
you have any questions about this
medicine ask your pharmacist. Keep
this leaflet; you may need to read it
again.
1.
What is Enahexal used for
2.
How Enahexal works
3.
Before you take Enahexal
4.
How to take Enahexal
5.
While you are using Enahexal
6.
Possible side effects
7.
How to store Enahexal
8.
Product description
9.
Marketing authorization holder and
manufacturer
WHAT IS ENAHEXAL USED FOR
Enahexal is used to treat high
blood pressure (hypertension) and
heart failure. Enahexal is often
used with other medicines called
diuretics or fluid tablets. These
medicines help the kidney get rid of
excess fluid from the body. Enahexal
is also commonly used with digitalis,
a medication for heart failure.
Ask your doctor if you have any
questions about why this medicine
has been prescribed for you. Your
doctor may have prescribed it for
another reason
HOW ENAHEXAL WORKS
Enahexal belongs to a group of
medicines known as angiotensin
converting enzyme (ACE) inhibitors.
These medicines work by widening
your blood vessels to make it easier
for the heart to pump blood through
them to all parts of your body. This
helps to reduce high blood pressure
and increase the supply of oxygen to
your heart, so that when you place
extra demand on your heart, such as
during exercise, your heart may cope
better and you may not get short of
breath

Ciri produk

Each ENAHEXAL® 5MG_ _tablet, ENAHEXAL® 10MG_ _tablet
and ENAHEXAL® 20MG_ _tablet contains enalapril maleate 20mg
DESCRIPTION
ENAHEXAL® 20MG:_ _Oval, convex, orange snap tab tablets, one
side scored with marking of EN 20.
MECHANISM(S) OF ACTION
Enalapril
maleate
is
a
prodrug
of
enalaprilat
and
has
little
pharmacologic activity until hydrolysed in vivo to enalaprilat. The
mechanism(s) of action of enalaprilat and enalapril maleate have not
been fully elucidated. The drugs appear to reduce blood pressure in
normotensive individuals and hypertensive patients and to produce
beneficial
hemodynamic
effects
in
patients
with
congestive
heart
failure
mainly
by
suppressing
the
renin-angiotensin-aldosterone
system. Following oral administration, enalapril is rapidly absorbed
and then hydrolysed to the active metabolite enalaprilat. Enalaprilat
exerts
its
effect
on
the
renin
angiotensin-aldosterone
system
by
inhibiting
the
angiotensin-converting
enzyme
(ACE).
It
reduces
peripheral arterial resistance. In heart failure, it reduces both
preload
and
afterload
and
the
cardiac
output
may
be
increased
without
significant change in heart rate.
ACE catalyses the conversion of angiotensin I to the vasoconstrictor
substance, angiotensin II. Angiotensin II also stimulates aldosterone
secretion by the adrenal cortex. The beneficial effects of enalapril
in
hypertension
and
heart
failure
appear
to
result
primarily
from
suppression of the renin-angiotensin-aldosterone system. Inhibition of
ACE
results
in
decreased
plasma
angiotensin
II,
which
leads
to
decreased
vasopressor
activity
and
to
decreased
aldosterone
secretion. Although the latter decrease is small, it results in small
increases of serum potassium.
ACE is identical to kininase, an enzyme that degrades bradykinin.
Whether
increased
levels
of
bradykinin,
a
potent
vasodepressor
peptide, play a role in the therapeutic effects of enalapril remains
to be
elucidated.
PHARMACOLOGY
Enalapril is structurally and pharmacologically similar to captopril,
but
contains a disubstituted nitrog