البلد: الولايات المتحدة
اللغة: الإنجليزية
المصدر: NLM (National Library of Medicine)
ivermectin (UNII: 8883YP2R6D) (IVERMECTIN - UNII:8883YP2R6D), CLORSULON (UNII: EG1ZDO6LRD) (CLORSULON - UNII:EG1ZDO6LRD)
Bimeda, Inc.
SUBCUTANEOUS
OTC
Approved by FDA under ANADA #200-450 Restricted Drug (California)-Use Only as Directed Bimectin® Plus (ivermectin and clorsulon) Injection for Cattle For the effective treatment and control of internal parasites, including adult liver flukes , and external parasites. Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism. INTRODUCTION The ability of ivermectin to deliver internal and external parasite control has been proven in cattle markets around the world. Now, Bimectin® Plus combines ivermectin, the active ingredient of Bimectin 1%, with clorsulon, an effective adult flukicide. A single injection of Bimectin® Plus (ivermectin and clorsulon) offers all the benefits of Bimectin 1% plus control of adult Fasciola hepatica . The dosage level of clorsulon supplied by Bimectin® Plus is effective only against adult liver flukes (Fasciola hepatica ). PRODUCT DESCRIPTION Bimectin® Plus is a ready-to-use sterile solution containing 1% w/v ivermectin, 10% w/v cl
Abbreviated New Animal Drug Application
BIMECTIN PLUS- IVERMECTIN CLORSULON INJECTION BIMEDA, INC. ---------- APPROVED BY FDA UNDER ANADA # 200-450 RESTRICTED DRUG (CALIFORNIA)-USE ONLY AS DIRECTED BIMECTIN® PLUS (IVERMECTIN AND CLORSULON) INJECTION FOR CATTLE FOR THE EFFECTIVE TREATMENT AND CONTROL OF INTERNAL PARASITES, INCLUDING ADULT LIVER FLUKES, AND EXTERNAL PARASITES. CONSULT YOUR VETERINARIAN FOR ASSISTANCE IN THE DIAGNOSIS, TREATMENT AND CONTROL OF PARASITISM. INTRODUCTION The ability of ivermectin to deliver internal and external parasite control has been proven in cattle markets around the world. Now, Bimectin® Plus combines ivermectin, the active ingredient of Bimectin 1%, with clorsulon, an effective adult flukicide. A single injection of Bimectin® Plus (ivermectin and clorsulon) offers all the benefits of Bimectin 1% plus control of adult _Fasciola hepatica_. THE DOSAGE LEVEL OF CLORSULON SUPPLIED BY BIMECTIN® PLUS IS EFFECTIVE ONLY AGAINST ADULT LIVER FLUKES (_FASCIOLA HEPATICA_). PRODUCT DESCRIPTION Bimectin® Plus is a ready-to-use sterile solution containing 1% w/v ivermectin, 10% w/v clorsulon, 40% glycerol formal, and propylene glycol, q.s. ad 100%. It is formulated to deliver the recommended dose level of 200 mcg ivermectin/kg and 2 mg clorsulon/kg given subcutaneously behind the shoulder at the rate of 1 mL per 110 lb (50 kg) body weight. MODE OF ACTION Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA). The margin of safety for compounds of this class is attributable to the fac اقرأ الوثيقة كاملة