البلد: جنوب أفريقيا
اللغة: الإنجليزية
المصدر: South African Health Products Regulatory Authority (SAHPRA)
Bm_squib
CEFRIL-A 250 mg Injection CEFRIL-A 500 mg Injection CEFRIL-A 1 g Injection CEFRIL-A 2 g Injection SCHEDULING STATUS S4 PROPRIETARY NAME (and dosage form) CEFRIL-A 250 mg Injection CEFRIL-A 500 mg Injection CEFRIL-A 1 g Injection CEFRIL-A 2 g Injection COMPOSITION CEFRIL -A is a sterile powder blend of cephradine and arginine base which is intended for intramuscular or intravenous administration after reconstitution. Each vial contains 250 mg, 500 mg, 1 g or 2 g cephradine . Cephradine is a semisynthetic cephalosporin chemically designated as 7 -[D-2-amino-2-(1,4-cyclo hexadien-1-yl) acetamidol] -3-methyl-8-oxo-5-thia-1-azobicyclo (4,2,0)oct-2-ene- 2-carboxylic acid. PHARMACOLOGICAL CLASSIFICATION Category A 20.1.1 Broad Spectrum Antibiotics PHARMACOLOGICAL ACTION Cephradine is a broad spectrum, bactericidal antibiotic active against both gram positive and gram negative bacteria. This antibiotic demonstrates high activity against most strains of penicillinase producing staphylococci and E.coli. Microbiology: The following organisms have shown sensitivity to cephradine in vitro: Gram positive: Staphylococci (both penicillin sensitive and resistant strains); Group A beta-hemolytic streptococci, and Streptococcus pneumoniae. Gram negative: Escherichia coli, Klebsiella species, Proteus mirabilis, Haemophilus influenzae, Cephradine is not active against most strains of Enterobacter species, Morganella morganii,andProteus vulgaris. Most strains of enterococci (Enterococcus faecalis)are resistant to cephradine. It has no activity against Pseudomonas or Herellea species. Because cephradine is unaffected by penicillinase, strains of E.Coli and Staphylococcus aureus that produce this enzyme may be susceptible to cephradine. When tested by in vitro methods, staphylococci exhibit cross resistance between cephradine and methici اقرأ الوثيقة كاملة