LISINOPRIL RANBAXY lisinopril 20 mg tablet blister pack

البلد: أستراليا

اللغة: الإنجليزية

المصدر: Department of Health (Therapeutic Goods Administration)

العنصر النشط:

lisinopril dihydrate

متاح من:

Sun Pharma ANZ Pty Ltd

INN (الاسم الدولي):

Lisinopril dihydrate

الوضع إذن:

Registered

نشرة المعلومات

Lisinopril Ranbaxy CMI V1 Feb 2009
Page 1
LISINOPRIL RANBAXY
LISINOPRIL DIHYDRATE_ _
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some
common questions about
LISINOPRIL RANBAXY.
It does not contain all the
available information. It does not
take the place of talking to your
doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has
weighed the risks of you taking
LISINOPRIL RANBAXY against the
benefits it is expected to have for
you.
IF YOU HAVE ANY CONCERNS
ABOUT TAKING THIS MEDICINE,
ASK YOUR DOCTOR OR
PHARMACIST.
KEEP THIS LEAFLET WITH THE
MEDICINE.
You may need to read it again.
WHAT LISINOPRIL
RANBAXY IS USED FOR
LISINOPRIL RANBAXY_ _is used to:

lower high blood pressure
(hypertension)

treat heart failure

treat patients who have just
had a heart attack
HYPERTENSION:
Everyone has blood pressure.
This pressure helps get your
blood all around your body.
Your blood pressure may be
different at different times of the
day, depending on how busy or
worried you are. You have
hypertension (high blood
pressure) when your blood
pressure stays higher than is
needed, even when you are
calm and relaxed.
There are usually no symptoms
of hypertension. The only way of
knowing that you have
hypertension is to have your
blood pressure checked on a
regular basis. If high blood
pressure is not treated it can
lead to serious health problems,
including stroke, heart disease
and kidney failure.
LISINOPRIL RANBAXY is used to
lower high blood pressure
(hypertension).
HEART FAILURE:
Heart failure means that the
heart muscle cannot pump blood
strongly enough to supply all the
blood needed throughout the
body. Heart failure is not the
same as heart attack and does
not mean that the heart stops
working.
Heart failure may start off with
no symptoms, but as the
condition progresses, people
may feel short of breath or may
get tired easily after light
physical activity such as walking.
Some people may wake up short
of breath at night. Fluid may
collect in different parts of the
body

خصائص المنتج

LISINOPRIL RANBAXY PI V1 Apr 09
Page 1
LISINOPRIL RANBAXY TABLETS
NAME OF THE DRUG
Active Ingredient:_ _
Lisinopril dihydrate.
Inactive Ingredients:
Mannitol, calcium hydrogen phosphate, Maize starch, Pregelatinised
maize
starch, magnesium stearate.
All strengths also contain iron oxide yellow (CI77492), while the 20
mg tablet
also contains iron oxide red (CI77491)
DESCRIPTION
Chemical Name:
_N_-[_N_-[(1_S_)-1-carboxy-3-phenylpropyl]-L-lysyl]-L-proline
dihydrate
Chemical Structure:
_ _
_ _
_ _
_ _
Molecular Formula:
C
21
H
31
N
3
O
5
.2H
2
O
Molecular Weight:
441.53
CAS Number:
83915-83-7_ _
A synthetic peptide derivative, lisinopril dihydrate is an oral
long-acting angiotensin converting enzyme
inhibitor. It is a lysine analogue of enalaprilat (active metabolite
of enalapril).
Lisinopril dihydrate is a white to off-white crystalline powder that
is soluble in water, sparingly soluble in
methanol and practically insoluble in ethanol.
PHARMACOLOGY
MECHANISM OF ACTION_ _
Lisinopril is a peptidyl dipeptidase inhibitor. It inhibits the
angiotensin converting enzyme (ACE) that
catalyses the conversion of angiotensin I to the vasoconstrictor
substance, angiotensin ll. Angiotensin
ll also stimulates aldosterone secretion by the adrenal cortex.
Inhibition of ACE results in decreased
concentrations of plasma angiotensin ll which results in decreased
vasopressor activity and to
decreased aldosterone secretion. The latter decrease may result in a
small increase of serum
potassium. In hypertensive patients with normal renal function treated
with lisinopril alone for up to
24 weeks,
the
mean
increase
in
serum
potassium
was
approximately
0.1
mmol/L;
however,
approximately 15% of patients had increases greater than 0.5 mmol/L
and approximately 6% had a
decrease
greater
than
0.5
mmol/L.
In
the
same
study,
patients
treated
with
lisinopril
and
hydrochlorothiazide for up to 24 weeks had a mean decrease in serum
potassium of 0.1 mmol/L;
approximately 4% of patients had increases greater than 0.5 mmol/L and
approximately 12% had a
N
N