البلد: أستراليا
اللغة: الإنجليزية
المصدر: Department of Health (Therapeutic Goods Administration)
Omeprazole
Ranbaxy Australia Pty Ltd
Medicine Registered
Omeprazole Ranbaxy CMI V2 Jun 2009 OMEPRAZOLE RANBAXY OMEPRAZOLE TABLETS CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some of the common questions about OMEPRAZOLE RANBAXY. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking OMEPRAZOLE RANBAXY against the benefits it is expected to have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT OMEPRAZOLE RANBAXY IS USED FOR _Peptic Ulcers _ OMEPRAZOLE RANBAXY is used to treat peptic ulcers. Depending on the position of the ulcer it is called a gastric or duodenal ulcer. A gastric ulcer occurs in the stomach. A duodenal ulcer occurs in the duodenum which is the tube leading out from the stomach. These ulcers can be caused by too much acid being made in the stomach. OMEPRAZOLE RANBAXY is also used to help stop peptic or duodenal ulcers coming back. _Peptic Ulcers Associated with _ _Helicobacter pylori Infection _ Most peptic ulcers are caused by an infection with the bacterium _Helicobacter pylori_ in the stomach. _H. pylorus_ weakens the protective mucous coating of the stomach and duodenum, which allows acid to get through to the sensitive lining beneath . Both the acid and the bacteria irritate the lining and cause a sore, or ulcer. When OMEPRAZOLE RANBAXY is taken together with an antibiotic, the combination will kill _H. pylori_ and let your peptic ulcer heal. _Peptic Ulcers Associated with _ _Non-Steroidal Anti-Inflammatory _ _Drugs (NSAIDs) _ Some peptic ulcers are caused by medicines called non- steroidal anti-inflammatory drugs. These medicines are co اقرأ الوثيقة كاملة
OMEPRAZOLE RBX PI V2 Jun09 Page 1 of 10 OMEPRAZOLE RANBAXY _PRODUCT INFORMATION _ OMEPRAZOLE RANBAXY (omeprazole) 20 mg tablets DESCRIPTION Chemical name: 5-methoxy-2-[(_RS_)-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-sulphinyl]-1_H_- benzimidazole. Omeprazole is a white or almost white powder, very slightly soluble in water, soluble in methylene chloride, sparingly soluble in alcohol and in methanol. It dissolves in dilute solutions of alkali hydroxides. Each tablet contains 20 mg of omeprazole and the following excipients: ascorbyl palmitate, cellulose- microcrystalline, crospovidone, magnesium stearate, povidone, lactose, talc purified, hypromellose phthalate, glycerol triacetate, iron oxide red (CI77491), iron oxide black (CI77499). Omeprazole has the empirical formula of C 17 H 19 N 3 O 3 S, a molecular weight of 345.4 and CAS number 73590-58-6. Structurally it is represented as: PHARMACOLOGY Omeprazole reversibly reduces gastric acid secretion by specifically inhibiting the gastric enzyme H+, K+-ATPase, the proton pump, in the acid environment of the intracellular canaliculi within the parietal cell. This effect of omeprazole on the final step of the gastric acid formation process is dose dependent and effectively inhibits both basal acid secretion and stimulated acid secretion, irrespective of the stimulus to acid production. Omeprazole has no effect on acetylcholine or histamine receptors. No clinically significant pharmacodynamic effects, other than those explained by the effect on acid secretion, have been observed. _EFFECT ON GASTRIC ACID SECRETION:_ Oral dosing with omeprazole 20 mg once daily provides rapid and effective reduction of gastric acid secretion. After a single dose the onset of antisecretory effect occurs within one hour and is اقرأ الوثيقة كاملة