البلد: أستراليا
اللغة: الإنجليزية
المصدر: Department of Health (Therapeutic Goods Administration)
paracetamol
Medis Pharma Pty Ltd
Paracetamol
Registered
_Paracetamol AN injection – Consumer Medicine Information_ Paracetamol AN CMI v3.0 Page 1 of 3 PARACETAMOL AN _Paracetamol _ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Paracetamol AN. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor or pharmacist has weighed the risks of you receiving Paracetamol AN against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT PARACETAMOL AN IS USED FOR Paracetamol AN contains paracetamol, an analgesic medicine which relieves pain and reduces fever. Paracetamol AN is a solution of paracetamol which is given by IV infusion directly into a vein, and is used to relieve pain or reduce fever following surgery. This medicine is available only with a doctor's prescription. BEFORE YOU ARE GIVEN PARACETAMOL AN _WHEN YOU MUST NOT _ _BE GIVEN PARACETAMOL _ _AN _ YOU MUST NOT BE GIVEN PARACETAMOL AN IF YOU HAVE AN ALLERGY TO PARACETAMOL OR TO ANY OF THE INGREDIENTS LISTED AT THE END OF THIS LEAFLET. Symptoms of an allergic reaction may include: * shortness of breath, wheezing or difficulty breathing * swelling of the face, lips, tongue or other parts of the body * rash, itching or hives on the skin YOU MUST NOT BE GIVEN PARACETAMOL AN IF YOU HAVE LIVER DISEASE. IF YOU ARE NOT SURE WHETHER YOU SHOULD BE GIVEN PARACETAMOL AN, TALK TO YOUR DOCTOR OR PHARMACIST. _BEFORE YOU ARE GIVEN _ _PARACETAMOL AN _ TELL YOUR DOCTOR OR PHARMACIST IF YOU HAVE ALLERGIES TO: * any other medicines * any other substances, such as foods, preservatives or dyes TELL YOUR DOCTOR OR PHARMACIST IF YOU ARE PREGNANT. Paracetamol AN may be given to pregnant women, but your doctor must be told if you are pregnant. TELL YOUR DOCTOR OR PHARMACIST IF YOU ARE BREAST-FEEDING. Paracetamol AN may be giv اقرأ الوثيقة كاملة
_Paracetamol AN injection Product Information _ _ _ _ Amneal Pharma Australia Pty Ltd_ Paracetamol AN PI v4.0 Page 1 of 18 Paracetamol AN PRODUCT INFORMATION NAME OF THE MEDICINE Paracetamol. The chemical name for paracetamol is 4-acetamidophenol. Its structural formula is: C 8 H 9 NO 2 Molecular weight: 151.2 CAS No.: 103-90-2 DESCRIPTION Paracetamol is a white, crystalline solid powder which is odourless or almost odourless and hygroscopic. It is soluble in water (1 in 70), soluble in alcohol (1 in 7), acetone (1 in 13), glycerol (1 in 40), propylene glycol (1 in 9) and also soluble in solutions of the alkali hydoxides. Paracetamol AN solution for infusion is a clear solution that contains 1000 mg/100 mL of paracetamol. The solution also contains mannitol, cysteine hydrochloride monohydrate, dibasic dihydrate sodium phosphate, sodium hydroxide, hydrochloric acid, water for injections. PHARMACOLOGY PHARMACODYNAMICS The precise mechanism of the analgesic and antipyretic properties of paracetamol has yet to be established; it may involve central and peripheral actions. Paracetamol 1000 mg/100 mL solution for infusion provides onset of pain relief within five to ten minutes after the start of administration. The peak analgesic effect is obtained in one hour and the duration of this effect is usually four to six hours. Paracetamol 1000 mg/100 mL solution for infusion reduces fever within 30 minutes after the start of administration with a duration of the antipyretic effect of at least 6 hours. PHARMACOKINETICS _ADULTS _ Absorption Paracetamol pharmacokinetics are linear after a single administration of up to 2 g and after repeated administration during 24 hours. _Paracetamol AN injection Product Information _ _ _ _ Amneal Pharma Australia Pty Ltd_ Paracetamol AN PI v4.0 Page 2 of 18 The bioavailability of paracetamol following infusion of paracetamol 1000 mg/100 mL is similar to that observed following infusion of propacetamol 2 g (containing paracetamol 1 g). For both these products, peak plasma concentration is ob اقرأ الوثيقة كاملة