País: Estats Units
Idioma: anglès
Font: NLM (National Library of Medicine)
CARPROFEN (UNII: FFL0D546HO) (CARPROFEN - UNII:FFL0D546HO)
Cronus Pharma LLC
ORAL
PRESCRIPTION
Carprofen Chewable Tablets are indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs. Carprofen Chewable Tablets should not be used in dogs exhibiting previous hypersensitivity to carprofen.
STORAGE: Store at 20°C to 25°C (68°F to 77°F), excursions permitted between 15°C and 30°C (between 59°F and 86°F). [See USP controlled room temperature.] Protect from light. HOW SUPPLIED: Carprofen Chewable Tablets are scored (except for the unscored 37.5 mg strength), and contain 25 mg, 50mg, 37.5 mg, 75 mg, or 100 mg of carprofen per tablet. Each tablet size is packaged in bottles containing 60 or 180 tablets.
Abbreviated New Animal Drug Application
CARPROFEN- CARPROFEN TABLET, CHEWABLE Cronus Pharma LLC ---------- Dog Owner Information about Carprofen Chewable Tablets (carprofen) for Osteoarthritis and Post-Surgical Pain This summary contains important information about Carprofen Chewable Tablets. You should read this information before you start giving your dog Carprofen Chewable Tablets and review it each time the prescription is refilled. This sheet is provided only as a summary and does not take the place of instructions from your veterinarian. Talk to your veterinarian if you do not understand any of this information or if you want to know more about Carprofen Chewable Tablets. What are Carprofen Chewable Tablets? Carprofen Chewable Tablets are a nonsteroidal anti-inflammatory drug (NSAID) that is used to reduce pain and inflammation (soreness) due to osteoarthritis and pain following surgery in dogs. Carprofen Chewable Tablets is a prescription drug for dogs. It is available as a chewable tablet and is given to dogs by mouth. Osteoarthritis (OA) is a painful condition caused by “wear and tear” of cartilage and other parts of the joints that may result in the following changes or signs in your dog: • Limping or lameness • Decreased activity or exercise (reluctance to stand, climb stairs, jump or run, or difficulty in performing these activities) • Stiffness or decreased movement of joints To control surgical pain (e.g. for surgeries such as spays, ear procedures or orthopedic repairs) your veterinarian may administer Carprofen Chewable Tablets before the procedure and recommend that your dog be treated for several days after going home. What kind of results can I expect when my dog is on Carprofen Chewable Tablets? While Carprofen Chewable Tablets are not a cure for osteoarthritis, it can relieve the pain and inflammation of OA and improve your dog’s mobility. • Response varies from dog to dog but can be quite dramatic. • In most dogs, improvement can be seen in a matter of days. • If Carprofen Chewable Tablets are discontinued or not Llegiu el document complet
CARPROFEN- CARPROFEN TABLET, CHEWABLE CRONUS PHARMA LLC ---------- CARPROFEN CHEWABLE TABLETS (CARPROFEN) _NON-STEROIDAL ANTI-INFLAMMATORY DRUG_ FOR ORAL USE IN DOGS ONLY CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION: Carprofen Chewable Tablets (carprofen) are a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class that includes ibuprofen, naproxen, and ketoprofen. Carprofen is the nonproprietary designation for a substituted carbazole, 6-chloro-α- methyl-9H-carbazole-2-acetic acid. The empirical formula is C H ClNO and the molecular weight 273.72. The chemical structure of carprofen is: Carprofen is a white, crystalline compound. It is freely soluble in ethanol, but practically insoluble in water at 25°C. CLINICAL PHARMACOLOGY Carprofen is a non-narcotic, non-steroidal anti-inflammatory agent with characteristic analgesic and antipyretic activity approximately equipotent to indomethacin in animal models . The mechanism of action of carprofen, like that of other NSAIDs, is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals . The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity. The specificity of a particular NSAID for COX-2 versus COX-1 may vary from species to species . In an _in vitro_ study using canine cell cultures, carprofen demonstrated selective inhibition of COX-2 versus COX-1. Clinical relevance of these data has not been shown. Carprofen has also been shown to inhibit the release of several prostaglandins in two inflammatory cell systems: rat polymorphonuclear leukocytes (PMN) and human rheumatoid synovial cells, indicating inhibition o Llegiu el document complet