Land: USA
Sprog: engelsk
Kilde: NLM (National Library of Medicine)
carprofen (UNII: FFL0D546HO) (carprofen - UNII:FFL0D546HO)
BUTLER ANIMAL HEALTH SUPPLY, LLC dba COVETRUS NORTH AMERICA
ORAL
PRESCRIPTION
Carprofen is indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs. Carprofen should not be used in dogs exhibiting previous hypersensitivity to carprofen.
Carprofen caplets are scored, and contain 25 mg, 75 mg, or 100 mg of carprofen per caplet. Each caplet size is packaged in bottles containing 60 or 180 caplets.
Abbreviated New Animal Drug Application
CARPROFEN- CARPROFEN TABLET BUTLER ANIMAL HEALTH SUPPLY, LLC DBA COVETRUS NORTH AMERICA ---------- COVETRUS ANADA 200-498, Approved by FDA CARPROFEN CAPLETS _NON-STEROIDAL ANTI-INFLAMMATORY DRUG_ FOR ORAL USE IN DOGS ONLY CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION: Carprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class that includes ibuprofen, naproxen, and ketoprofen. Carprofen is the nonproprietary designation for a substituted carbazole, 6-chloro- -methyl-9H-carbazole-2-acetic acid. The empirical formula is C H ClNO and the molecular weight 273.72. The chemical structure of carprofen is: Carprofen is a white, crystalline compound. It is freely soluble in ethanol, but practically insoluble in water at 25°C. CLINICAL PHARMACOLOGY: Carprofen is a non-narcotic, non-steroidal anti-inflammatory agent with characteristic analgesic and antipyretic activity approximately equipotent to indomethacin in animal models. The mechanism of action of carprofen, like that of other NSAlDs, is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity. The specificity of a particular NSAID for COX-2 versus COX-1 may vary from species to species. In an _IN VITRO_ study using canine cell cultures, carprofen demonstrated selective inhibition of COX-2 versus COX-1. Clinical relevance of these data has not been shown. Carprofen has also been shown to inhibit the release of several prostaglandins in two inflammatory cell systems: rat polymorphonuclear leukocytes (PMN) and human rheumatoid synovial cells, indica Læs hele dokumentet