Land: Sydafrika
Sprog: engelsk
Kilde: South African Health Products Regulatory Authority (SAHPRA)
Lennon
CLOXlN 125 mg/mL SYRUP CLOXIN 250 mg CAPSULES CLOXlN 500 mg CAPSULES SCHEDULING STATUS: S4 PROPRIETARY NAME (and dosage form): CLOXlN 125 mg/mL SYRUP CLOXIN 250 mg CAPSULES CLOXlN 500 mg CAPSULES COMPOSITION: Syrup: When reconstituted as directed, each 5 mL of the syrup contains cloxacillin sodium equivalent to 125 mg cloxacillin. Preservative: sodium benzoate 0,1% m/v. Capsules: Each capsule contains cloxacillin sodium equivalent to 250 mg or 500 mg cloxacillin. PHARMACOLOGICAL CLASSIFICATION: A 20.1.2 Penicillins. PHARMACOLOGICAL ACTION: Cloxacillin is a semi-synthetic penicillin, resistant to penicillinase, and is therefore active against penicillinase- producing staphylococci. Cloxacillin is in general less effective against organisms susceptible to benzylpenicillin, such as streptococci, pneumococci and non-penicillinase-producing staphylococci, and is not useful against gram-negative bacteria. INDICATIONS: Cloxacillin is indicated for the treatment of infections due to penicillinase-producing staphylococci that are resistant to benzylpenicillin. It is used against gram-positive staphylococcus aureus in: skin and soft tissue infections, e.g. abscesses, cellulitis. pneumonia endocarditis osteomyelitis CONTRA-INDICATIONS: Cloxacillin should not be given to patients with a history of penicillin allergy or administered to neonates born of mothers hypersensitive to penicillin. Patients allergic to cephalosporins may also be allergic to penicillins. Cloxacillin is incompatible with aminoglycosides, tetracyclines, erythromycin and polymyxin B. WARNINGS: Use with caution in patients with a known history of allergy to penicillins. When administered to a patient with penicillin sensitivity anaphylactic shock may occur. Adrenaline, corticosteroids and antihistamines should be used to treat anaphylaxis. Due to Læs hele dokumentet