Land: Südafrika
Sprache: Englisch
Quelle: South African Health Products Regulatory Authority (SAHPRA)
Lennon
MORPHINE SULPHATE PF INJECTION INTRAMED 10 mg/mL MORPHINE SULPHATE PF INJECTION INTRAMED 15 mg/mL MORPHINE SULPHATE PF INJECTION INTRAMED 20 mg/mL SCHEDULING STATUS: S7 PROPRIETARY NAME (and dosage form): MORPHINE SULPHATE PF INJECTION INTRAMED 10 mg/mL MORPHINE SULPHATE PF INJECTION INTRAMED 15 mg/mL MORPHINE SULPHATE PF INJECTION INTRAMED 20 mg/mL COMPOSITION: Each 1 mL ampoule contains 10, 15 or 20 mg morphine sulphate. PHARMACOLOGICAL CLASSIFICATION: A 2.9 Other analgesics PHARMACOLOGICAL ACTION: Morphine acts as an agonist particularly at µ receptors, and also d and K-receptors. Its effects are diverse and include analgesia, drowsiness, changes in mood, respiratory depression, decreased gastrointestinal motility, nausea, vomiting and alterations of the endocrine and autonomic nervous systems. The development of tolerance and physical dependence is a characteristic feature. About one third is protein bound and it has a half-life of about 2 hours. It is eliminated mainly by glomerular filtration and small amounts are found in the faeces and urine. INDICATIONS: Relief of intractable pain not controlled with non-narcotic analgesics. CONTRA-INDICATIONS: Morphine is not usually administered to children under the age of one year and it should be given with extreme care to newborn or premature infants. It is contra-indicated in: – respiratory depression, especially in the presence of cyanosis and excessive bronchial secretion; – in the presence of acute alcoholism, head injuries and conditions in which intracranial pressure is raised; – during an attack of bronchial asthma or in heart failure secondary to chronic lung disease; – for biliary or renal colic, since sphincter constriction occurs. WARNINGS: The euphoric activity of morphine may lead to abuse. Dependence and toleran Lesen Sie das vollständige Dokument