Χώρα: Ηνωμένες Πολιτείες
Γλώσσα: Αγγλικά
Πηγή: NLM (National Library of Medicine)
AMOXICILLIN (UNII: 804826J2HU) (AMOXICILLIN - UNII:804826J2HU), CLAVULANATE POTASSIUM (UNII: Q42OMW3AT8) (CLAVULANIC ACID - UNII:23521W1S24)
State of Florida DOH Central Pharmacy
AMOXICILLIN
AMOXICILLIN 875 mg
ORAL
PRESCRIPTION DRUG
Amoxicillin/clavulanate potassium is indicated in the treatment of infections caused by susceptible strains of the designated organisms in the conditions listed below: Lower Respiratory Tract Infections - caused by β-lactamase-producing strains of H. influenzae and M. catarrhalis. Otitis Media - caused by β-lactamase-producing strains of H. influenzae and M. catarrhalis. Sinusitis - caused by β-lactamase-producing strains of H. influenzae and M. catarrhalis. Skin and Skin Structure Infections - caused by β-lactamase-producing strains of S. aureus, E. coli and Klebsiella spp. Urinary Tract Infections - caused by β-lactamase-producing strains of E. coli , Klebsiella spp. and Enterobacter spp. While amoxicillin/clavulanate potassium is indicated only for the conditions listed above, infections caused by ampicillin-susceptible organisms are also amenable to amoxicillin/clavulanate potassium treatment due to its amoxicillin content, therefore, mixed infections caused by ampicillin-susceptible orga
Amoxicillin and Clavulanate Potassium Tablets, USP 500/125 mg are white to off-white, oblong film coated tablets with beveled edges, debossed with 500/125 on one side and AMC on the other side. Amoxicillin and Clavulanate Potassium Tablets, USP 875/125 mg are white to off-white, oblong film coated tablets with beveled edges, scored and debossed with 875/125 on one side and AMC on the other side. They are supplied by State of Florida DOH Central Pharmacy as follows: Store tablets at 20 - 25°C (68 - 77°F) [See USP Controlled Room Temperature]. Dispense in tightly closed, moisture-proof containers.
Abbreviated New Drug Application
AMOXICILLIN AND CLAVULANATE POTASSIUM - AMOXICILLIN AND CLAVULANATE POTASSIUM TABLET, FILM COATED STATE OF FLORIDA DOH CENTRAL PHARMACY ---------- AMOXICILLIN AND CLAVULANATE POTASSIUM TABLETS, USP AMOXICILLIN, 500 mg, as the trihydrate and CLAVULANIC ACID, 125 mg, as clavulanate potassium; or AMOXICILLIN, 875 mg, as the trihydrate and CLAVULANIC ACID, 125 mg, as clavulanate potassium Rx only PRESCRIBING INFORMATION To reduce the development of drug-resistant bacteria and maintain the effectiveness of Amoxicillin and Clavulanate Potassium Tablets, USP and other antibacterial drugs, Amoxicillin and Clavulanate Potassium Tablets, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. DESCRIPTION Amoxicillin and Clavulanate Potassium Tablet USP is an oral antibacterial combination consisting of the semisynthetic antibiotic amoxicillin and the β-lactamase inhibitor, clavulanate potassium (the potassium salt of clavulanic acid). Amoxicillin is an analog of ampicillin, derived from the basic penicillin nucleus, 6-aminopenicillanic acid. The amoxicillin molecular formula is C H N O S·3H O and the molecular weight is 419.46. Chemically, amoxicillin is _(2S, 5R, 6R)_-6-[(_R_)-(-)-2-Amino-2-(_p_- hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate and may be represented structurally as: Clavulanic acid is produced by the fermentation of _Streptomyces clavuligerus_. It is a β-lactam structurally related to the penicillins and possesses the ability to inactivate a wide variety of β-lactamases by blocking the active sites of these enzymes. Clavulanic acid is particularly active against the clinically important plasmid mediated β-lactamases frequently responsible for transferred drug resistance to penicillins and cephalosporins. The clavulanate potassium molecular formula is C H KNO and the molecular weight is 237.25. Chemically, clavulanate potassium is potassium (_Z_)-(2_R,_5_R_ )-3-(2- hydroxyethyliden Διαβάστε το πλήρες έγγραφο