CARPROFEN tablet

Χώρα: Ηνωμένες Πολιτείες

Γλώσσα: Αγγλικά

Πηγή: NLM (National Library of Medicine)

Δραστική ουσία:

Carprofen (UNII: FFL0D546HO) (Carprofen - UNII:FFL0D546HO)

Διαθέσιμο από:

BUTLER ANIMAL HEALTH SUPPLY, LLC DBA COVETRUS NORTH AMERICA

Οδός χορήγησης:

ORAL

Τρόπος διάθεσης:

PRESCRIPTION

Θεραπευτικές ενδείξεις:

Carprofen Tablets are indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs. Carprofen Tablets should not be used in dogs exhibiting previous hypersensitivity to carprofen.

Περίληψη προϊόντος:

Carprofen Tablets are scored, and contain 25 mg, 75 mg, or 100 mg of carprofen per caplet. Each caplet size is packaged in bottles containing  60, or 180 caplets.

Καθεστώς αδειοδότησης:

Abbreviated New Animal Drug Application

Φύλλο οδηγιών χρήσης

CARPROFEN - CARPROFEN TABLET
BUTLER ANIMAL HEALTH SUPPLY, LLC DBA COVETRUS NORTH AMERICA
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SPL MEDGUIDE
Dog Owner Information about
Carprofen Tablets
for Osteoarthritis and Post-Surgical Pain
Generic name: carprofen ("car-pro-fen")
This summary contains important information about Carprofen Tablets.
You should read this information
before you start giving your dog Carprofen Tablets and review it each
time the prescription is refilled. This
sheet is provided only as a summary and does not take the place of
instructions from your veterinarian. Talk
to your veterinarian if you do not understand any of this information
or if you want to know more about
Carprofen Tablets.
What are Carprofen Tablets?
Carprofen Tablets are a nonsteroidal anti-inflammatory drug (NSAID)
that is used to reduce pain and
inflammation (soreness) due to osteoarthritis and pain following
surgery in dogs. Carprofen Tablets are a
prescription drug for dogs. They are available as a caplet and are
given to dogs by mouth.
Osteoarthritis (OA) is a painful condition caused by “wear and
tear” of cartilage and other parts of the joints
that may result in the following changes or signs in your dog:
• Limping or lameness
• Decreased activity or exercise (reluctance to stand, climb stairs,
jump or run, or difficulty in performing
these activities)
• Stiffness or decreased movement of joints
To control surgical pain (e.g. for surgeries such as spays, ear
procedures or orthopedic repairs) your
veterinarian may administer Carprofen Tablets before the procedure and
recommend that your dog be treated
for several days after going home.
What kind of results can I expect when my dog is on Carprofen Tablets?
While Carprofen Tablets are not a cure for osteoarthritis, they can
relieve the pain and inflammation of OA
and improve your dog's mobility.
• Response varies from dog to dog but can be quite dramatic.
• In most dogs, improvement can be seen in a matter of days.
• If Carprofen Tablets are discontinued or not given as directed,
your dog'

Αρχείο Π.Χ.Π.

CARPROFEN - CARPROFEN TABLET
BUTLER ANIMAL HEALTH SUPPLY, LLC DBA COVETRUS NORTH AMERICA
----------
CARPROFEN TABLETS
CAPLETS
NON-STEROIDAL ANTI-INFLAMMATORY DRUG
FOR ORAL USE IN DOGS ONLY
CAUTION
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION
Carprofen is a non-steroidal anti-inflammatory drug (NSAID) of the
propionic acid class
that includes ibuprofen, naproxen, and ketoprofen. Carprofen is the
nonproprietary
designation for a substituted carbazole,
6-chloro-α-methyl-9_H_-carbazole-2-acetic acid.
The empirical formula is C
H
CINO and the molecular weight 273.72. The
chemical structure of carprofen is:
Carprofen is a white, crystalline compound. It is freely soluble in
ethanol, but practically
insoluble in water at 25ºC.
CLINICAL PHARMACOLOGY
Carprofen is a non-narcotic, non-steroidal anti-inflammatory agent
with
characteristic analgesic and antipyretic activity approximately
equipotent to
indomethacin in animal models.
The mechanism of action of carprofen, like that of other NSAIDs, is
believed to be
associated with the inhibition of cyclooxygenase activity. Two unique
cyclooxygenases
have been described in mammals.
The constitutive cyclooxygenase, COX-1,
synthesizes prostaglandins necessary for normal gastrointestinal and
renal function.
The inducible cyclooxygenase, COX-2, generates prostaglandins involved
in
inflammation. Inhibition of COX-1 is thought to be associated with
gastrointestinal and
15
12
2
1
2
renal toxicity while inhibition of COX-2 provides anti-inflammatory
activity. The specificity
of a particular NSAID for COX-2 versus COX-1 may vary from species to
species.
In an
_in vitro_ study using canine cell cultures, carprofen demonstrated
selective inhibition of
COX-2 versus COX-1.
Clinical relevance of these data has not been shown.
Carprofen has also been shown to inhibit the release of several
prostaglandins in two
inflammatory cell systems: rat polymorphonuclear leukocytes (PMN) and
human
rheumatoid synovial cells, indicating inhibition of ac