Χώρα: Μαλαισία
Γλώσσα: Αγγλικά
Πηγή: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Cimicoxib
Gladron Chemicals Sdn Bhd
Cimicoxib
144 Tablets; 32 Tablets
Vetoquinol SA
Not Applicable Διαβάστε το πλήρες έγγραφο
CIMALGEX 8 MG CHEWABLE TABLETS FOR DOGS CIMALGEX 30 MG CHEWABLE TABLETS FOR DOGS CIMALGEX 80 MG CHEWABLE TABLETS FOR DOGS CIMICOXIB STATEMENT OF THE ACTIVE SUBSTANCE AND OTHER INGREDIENTS Each tablet contains: Cimicoxib 8 mg Cimicoxib 30 mg Cimicoxib 80 mg Cimalgex 8 mg tablets: oblong tablets (10x4mm), white to beige, brown spotted, with one break-line on both sides. Cimalgex 30 mg tablets: Oblong tablets (15x6.5mm), white to beige, brown spotted, with 2 parallel breaking lines on both sides. Cimalgex 80 mg tablets: Oblong tablets (21.5x8.5mm), white to beige, brown spotted, with 3 parallel breaking lines on both sides. PHARMACODYNAMICS Cimicoxib is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID). It selectively inhibits the cyclooxygenase 2 enzyme (COX-2), which is responsible for pain, inflammation or fever. The cyclooxygenase 1 enzyme (COX-1) which has protective functions, for example, in the digestive tract and kidneys, is not inhibited by cimicoxib. PHARMACOKINETICS After oral administration in dogs at the recommended doses, cimicoxib is rapidly absorbed. Metabolism of cimicoxib is extensive. The major metabolite, demethylated cimicoxib is mainly eliminated in faeces by the biliary route and, to a lesser extent, in urine. The other metabolite, glucuronide conjugate of the demethy- lated cimicoxib, is eliminated in urine. In an artificially induced pain model in dogs it was shown that the pain and inflammation reducing effects of cimicoxib lasted for approximately 10-14 hours. DISPOSAL OF CONTAINERS Medicines should not be disposed of via wastewater or household waste. Ask your veterinary surgeon how to dispose of medicines no longer required. These measures should help to protect the environment. DIRECTION FOR USE For the treatment of pain and inflammation associated with osteoarthritis, and the management of peri-operative pain due to orthopaedic or soft tissue surgery, in dogs. DOSAGE AND ADMINISTRATION Oral use. The recommended dose of cimicoxib is 2 mg per kg bodyweight, once daily. The fo Διαβάστε το πλήρες έγγραφο