KHC FLUBENDAZOLE 50MGG PREMIX POWDER

Χώρα: Μαλαισία

Γλώσσα: Αγγλικά

Πηγή: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Δραστική ουσία:

FLUBENDAZOLE

Διαθέσιμο από:

KHENG HONG CHAN FARMING SDN BHD

INN (Διεθνής Όνομα):

FLUBENDAZOLE

Κατασκευάζεται από:

Thye Pharma Sdn. Bhd

Αρχείο Π.Χ.Π.

Veterinary Package Insert
KHC
Flubendazole
50MG/G
Premix
Powder
PRODUCT DESCRIPTION
White
or
almost
white
colour
powder,
which
contains 50mg of flubendazole per gram in 500gm
or 1kg sachet.
PHARMACODYNAMICS & PHARMACOKINETICS
Flubendazole acts by binding to tubulin, the dimeric
subunit protein of the microtubules. It inhibits
microtubular assembly in absorptive cells: i.e. of
intestinal cells of nematodes or the tegumental
cells of cestodes. This is shown by disappearance
of
cytoplasmic
microtubules,
accumulation
of
secretory granules in the cytoplasm due to a block
in their transport, leading to an impaired coating of
the cellular membrane and a decreased digestion
and
absorption
of
nutrients.
Irreversible
lytic
degeneration of the cell, due to the accumulation
of secretory substances (hydrolytic and proteolytic
enzymes), results in the death of the parasite.
These changes are relatively fast and are primarily
seen in those organelles directly involved in the
secretory and absorptive functions of the cells. In
contrast the changes are not seen in host cells.
Flubendazole
is
very
poorly
soluble
in
aqueous
systems, such as the gastrointestinal tract, which
results in a low dissolution rate and a very low
absorption.
This
is
reflected
by
a
high
faecal
excretion of unchanged parent drug. The very small
fraction
absorbed
is
extensively
metabolised
by
first-pass
metabolism
in
the
liver,
involving
carbamate hydrolysis and ketone reduction. The
biotransformation
products
are
conjugated
to
glucuronides or sulphate conjugates and excreted
in the bile and the urine.
The excretion in urine is relatively low and consists
almost exclusively of metabolites with only small
amounts of unchanged compound. In pigs, highest
tissue levels are measured in liver and kidneys.
The half-life of flubendazole in tissues is 1 to 2
days.
INDICATION
Flubendazole
is
a
broad
spectrum
anthelmintic,
effective against mature and immature stages of
the
following
nematodes
of
the
gastro-intestinal
tract:
Ascaris
suum,
(large
roundworm)
including
mig