Χώρα: Αυστραλία
Γλώσσα: Αγγλικά
Πηγή: Department of Health (Therapeutic Goods Administration)
Phenobarbitone; Phenobarbitone sodium
Aspen Pharma Pty Ltd
Medicine Registered
Phenobarbitone Injection/ Phenobarbitone Aspen Tablets - PI Page 1 of 15 PRODUCT INFORMATION NAME OF THE MEDICINE PHENOBARBITONE INJECTION contains phenobarbitone sodium 219 mg (equivalent to phenobarbitone 200 mg) per 1 mL ampoule. PHENOBARBITONE ASPEN TABLETS contain phenobarbitone 30 mg per tablet. DESCRIPTION PHENOBARBITONE presents as colourless crystals or a white odourless crystalline powder. It may exhibit polymorphism. It is soluble 1 in 1000 of water and 1 in 10 of alcohol; sparingly soluble in chloroform; soluble in ether. A saturated solution in water has a pH of about 5. PHENOBARBITONE SODIUM is a white, odourless, hygroscopic powder, granules or flakes. It is very soluble in water and soluble in alcohol, practically insoluble in chloroform and ether. A 10% solution in water has a pH of not more than 10.2. Store in airtight containers. PHENOBARBITONE (CAS -50–06–6) has the following chemical structure: N N O H O O H Et (phenobarbitone base) Its molecular formula is C 12 H 12 N 2 O 3 . The molecular weight is 232.2. PHENOBARBITONE SODIUM (CAS -57-30-7) has the following chemical structure: Its molecular formula is C 12 H 11 N 2 NaO 3 . The molecular weight is 254.2. N N Et O ONa O H Phenobarbitone Injection/ Phenobarbitone Aspen Tablets - PI Page 2 of 15 PHENOBARBITONE INJECTION contains the following excipients: ethanol, propylene glycol, water for injections . PHENOBARBITONE ASPEN TABLETS contain the following excipients: lactose, acacia, starch- wheat, magnesium stearate. PHARMACOLOGY ACTIONS Phenobarbitone is a long acting barbiturate used as a sedative-hypnotic and as an anticonvulsant in the treatment of epilepsy. Recent studies have suggested that the sedative-hypnotic and anticonvulsant effec Διαβάστε το πλήρες έγγραφο