ADRONAT
Country: Australia
Language: English
Source: Department of Health (Therapeutic Goods Administration)
Summary of Product characteristics
(SPC)
30-05-2024
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Active ingredient:
Alendronate sodium
Available from:
Merck Sharp & Dohme Australia Pty Ltd
Class:
Medicine Registered
Summary of Product characteristics
FSM-MF-032010s
1
PRODUCT INFORMATION
ADRONAT
®
(ALENDRONATE SODIUM)
ADRONAT® PLUS
(ALENDRONATE SODIUM/COLECALCIFEROL)
ADRONAT PLUS D-CAL
TM
(ALENDRONATE SODIUM/COLECALCIFEROL/CALCIUM)
TABLETS
ADRONAT tablets contain alendronate sodium.
ADRONAT PLUS tablets contain alendronate sodium and
colecalciferol (vitamin D
3
)
ADRONAT PLUS
D-Cal is a combination pack containing ADRONAT PLUS
(alendronate sodium and
colecalciferol [vitamin D3]) in addition to BoneCal
®
tablets (calcium carbonate)
Alendronate
sodium is described chemically as: (4-amino-1-hydroxybutylidene) bisphosphonic acid
monosodium salt trihydrate.
The empirical formula is C4H12NNaO7P2•3H2O. The formula weight
is 325.12. The CAS Registry Number is
121268-17-5. The structural formula is:
Colecalciferol
The chemical name
of colecalciferol is (3β,5_Z_,7_E_)-9,10-secocholesta-5,7,10(19)-trien-3-ol.
The empirical
formula of colecalciferol is C
27
H
44
O and its molecular weight is 384.6. The CAS Registry
Number is 67-97-0.
The structural formula is:
CH
2
H
HO
CH
3
H
H
CH
3
H
CH
3
H
3
C
® Registered Trademark of Merck Sharp & Dohme Corp., a
subsidiary of Merck & Co., Inc., Whitehouse Station, NJ, USA
TM Trademark of Merck Sharp & Dohme Corp., a subsidiary of Merck
& Co., Inc., Whitehouse Station, NJ, USA
FSM-MF-032010s
2
Calcium carbonate
Calcium carbonate is described chemically as carbonic acid calcium
salt (1:1). The empirical formula of calcium
carbonate is CaCo
3
and its molecular weight is 100.09. The CAS Registry Number
is 471-34-1.
DESCRIPTION
Alendronate sodium, MSD is a bisphosphonate that acts as a
potent, specific inhibitor of osteoclast-mediated
bone resorption. Bisphosphonates are
synthetic analogs of pyrophosphate that bind to
the hydroxyapatite found
in
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