Analgin GIGAfarm tablets

Country: Armenia

Language: English

Source: Դեղերի և բժշկական տեխնոլոգիաների փորձագիտական կենտրոնի գործունեության Հայաստանի Հանրապետությունում

Active ingredient:

metamizole (metamizole sodium)

Available from:

Arpimed LLC

ATC code:

N02BB02

INN (International Name):

metamizole (metamizole sodium)

Dosage:

500mg

Pharmaceutical form:

tablets

Units in package:

(200/20x10/) in blister

Prescription type:

OTC

Authorization status:

Registered

Authorization date:

2019-11-22

Summary of Product characteristics

SUMMARY PRODUCT CHARACTERISTIC (SPC)
ANALGIN GIGAFARM
500 MG TABLETS
BRAND NAME – ANALGIN GIGAfarm
GENERIC NAME – Metamizole sodium (Dipyrone)
COMPOSITION
Each tablet_ _contains:
_ACTIVE INGREDIENT: _metamizole sodium – 500 mg;
_INACTIVE INGREDIENTS:_ microcrystalline cellulose, lactose
monohydrate, maize starch, sodium starch
glycolate, magnesium stearate, talc purified.
PHARMACOLOGICAL GROUP AND ATC CODE
Analgesic-antipyretic; N02BB02.
PHARMACOLOGY
ANALGIN (metamizole) is a medicine of the pyrazolone group, possessing
hard analgesic and
antipyretic effects and moderate antiinflammatory activity. Blocking
of the synthesis of endogenous
pyrogens - prostaglandins D and E - is the cause for the antipyretic
activity and also for the analgesic
action of this drug. The decrease of the prostaglandis production in
the periphery (and respective
decrease
of
nerve
endings
sensitivity)
plays
a
relatively
smaller
role.
In
contrast
to
the
other
nonnarcotic analgesic drugs, metamizole stimulates the release of
β-endorphins, explaining its activity
in cases of visceral pain. Metamizole has a slight spasmolytic
activity on the smooth muscle cells of
the biliary and urinary tracts and also on the muscle of the uterus.
PHARMACOKINETICS
After oral doses metamizole is rapidly hydrolysed in gastric juice to
the active metabolite 4-methyl-
amino-antipyrine which after absorption undergoes metabolism to 4-
methyl-amino-antipyrine and
other metabolites. None of the metabolites of metamizole are
extensively bound to plasma proteins.
Most of a dose is excreted in the urine as metabolites. Metamizole
metabolites are also distributed into
breast milk.
Action develops in 20-40 minutes and reaches to the maximum after 2 h.
USES
ANALGIN GIGAfarm tablets are used for the treatment of pains of
different origin and variable
intensity:
-
toothache, headache, arthralgia, neuralgia, myalgia (in case of other
analgesic medications
inefficiency);
-
fever with colds and infectious-inflammatory diseases. ADMINISTRATION
The dosage and duration of