Country: Australia
Language: English
Source: Department of Health (Therapeutic Goods Administration)
Cyproterone acetate
Bayer Australia Ltd
Medicine Registered
1309 ANDROCUR ® CMI Page 1 of 5 ANDROCUR ® (ANNE·DRO·CUR) _ _ _cyproterone acetate _ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Androcur. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking Androcur against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT ANDROCUR IS USED FOR Androcur is an anti-androgen medicine. Androgens such as testosterone are natural male sex hormones which are also produced, to a slight extent, in females. MEN: In men, androgens may help cancer cells to grow in some types of prostate cancer. By blocking these hormones, Androcur may slow or stop the growth of cancer. Androcur may also be used in combination with other medicines or following surgical removal of the testes to treat side effects such as “hot flushes” or “sweats” and to prevent any initial worsening of the disease. Androcur is also used to reduce abnormal sex drive in men. WOMEN: In women, androgens may increase hair growth, loss of scalp hair and secretion of oil from the sweat glands. By blocking these hormones, Androcur may slow or stop excessive hairiness, loss of scalp hair, acne, oily skin and dandruff. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY THIS MEDICINE HAS BEEN PRESCRIBED FOR YOU. Your doctor may have prescribed it for another reason. This medicine is available only with a doctor’s pr Read the complete document
ANDROCUR ® PRODUCT INFORMATION NAME OF THE MEDICINE Androcur 10mg and Androcur 50mg Each pack contains tablets containing either 10mg or 50mg cyproterone acetate. Cyproterone acetate: CH 3 CH 3 H H H O O CH 3 O Cl O Chemical Name: 6-chloro-17 α hydroxy-1α,2α-methylene-pregna-4,6-diene-3,20-dione actetate Molecular Formula: C 24 H 29 CIO 4 Molecular Mass: 416.96 CAS No.: 427-51-0 DESCRIPTION Cyproterone acetate is a white to pale yellow crystalline powder. M.P. 206-213 °C. Cyproterone acetate is very soluble in chloroform and dioxane, freely soluble in acetone and benzene, soluble in ethanol, methanol and ethyl acetate, sparingly soluble in solvent hexane, and almost insoluble in water. PHARMACOLOGY Androcur is an antiandrogenic hormone preparation. Cyproterone acetate inhibits competitively the effect of androgens at androgen-dependent target organs, e.g. it shields the prostate from the effect of androgens originating from the gonads and/or the adrenal cortex. Prostatic carcinoma and its metastases are in general androgen-dependent, Androcur therefore exerts a direct antiandrogenic action on the tumour and its metastases. Cyproterone acetate in addition has a progestogenic action exerting a negative feedback effect centrally on the hypothalamic receptors, so leading to a reduction in gonadotropin release, and hence to diminished production of testicular androgens. Treatment with cyproterone acetate in men results in a reduction of sexual drive and potency and inhibition of gonadal function. These changes are reversible following discontinuation of the therapy. The antigonadotropic effect of cyproterone acetate is also exerted when the substance is combined with LHRH agonists. The initial increase of testosterone provoked by this substance group is decreased by cyproterone acetate. 101109 ANDROCUR 10 mg, 50 mg PI Read the complete document