Country: Malaysia
Language: English
Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
ETORICOXIB
KOTRA PHARMA (M) SDN. BHD.
ETORICOXIB
100 Tablets; 3x10tablet Tablets
KOTRA PHARMA (M) SDN. BHD.
AXCEL ETORICOXIB-90MG TABLET _Etoricoxib 90mg _ _ _ _ _ 1 _Consumer Medication Information Leaflet (RiMUP) _ WHAT IS IN THIS LEAFLET 1. What Axcel Etoricoxib-90mg Tablet is used for. 2. How Axcel Etoricoxib-90mg Tablet works. 3. Before you use Axcel Etoricoxib-90mg Tablet. 4. How to use Axcel Etoricoxib- 90mg Tablet. 5. While you are using it. 6. Side effects. 7. Storage and disposal of Axcel Etoricoxib-90mg Tablet. 8. Product description. 9. Manufacturer and Product Registration Holder. 10. Date of revision. WHAT AXCEL ETORICOXIB-90MG TABLET IS USED FOR It helps to reduce the pain and swelling (inflammation) in the joints and muscles of people with osteoarthiritis, rheumatoid arthritis, ankylosing spondylitis and gout. It is also use for the treatment of acute pain, including that related to menstrual pain and minor dental procedures. _What is osteoarthritis? _ Osteoarthritis is a disease of the joints. It results from the gradual breakdown of cartilage that cushions the ends of the bones. This causes swelling (inflammation), pain, tenderness, stiffness and disability. _What is rheumatoid arthritis? _ Rheumatoid arthritis is a long term inflammatory disease of the joints. It causes pain, stiffness, swelling, and increasing loss of movement in the joints it affects. It may also cause inflammation in other areas of the body. _What is gout? _ Gout is a disease of sudden, recurring attacks of very painful inflammation and redness in the joints. It is caused by deposits of mineral crystals in the joint. _What is ankylosing spondylitis? _ Ankylosing spondylitis is an inflammatory disease of the spine and large joints. HOW AXCEL ETORICOXIB-90MG TABLET WORKS Etoricoxib is one of a group of medicines called selective COX-2 inhibitors. These belong to a family of medicines called non-steroidal anti-inflammatory drugs (NSAIDs), that exhibits anti-inflammatory, analgesic, and antipyretic activities. BEFORE YOU USE AXCEL ETORICOXIB- 90MG TABLET _When you must not use it _ You must not use Axcel Etoricoxib- 90mg Tablet if you Read the complete document
AXCEL ETORICOXIB - 90MG TABLET COMPOSITION: Each tablet contains: Etoricoxib 90mg PRESENTATION: White coloured, round shape with 8.0mm diameter, biconvex, embossed with ‘Kotra’ logo on one side and breakline on the other side. AXCEL ETORICOXIB - 120MG TABLET COMPOSITION: Each tablet contains Etoricoxib 120mg PRESENTATION: Green coloured, round shape with 9.8mm diameter, biconvex, embossed with ‘Kotra’ logo on one side and breakline on the other side. INDICATIONS: For acute and chronic treatment of the signs and symptoms of osteoarthritis (OA) and rheumatoid arthritis (RA). Treatment of ankylosing spondylitis (AS), acute gouty arthritis, and acute pain, including that related to primary dysmenorrhoea and minor dental procedures. The decision to prescribe a selective COX-2 inhibitor should be based on an assessment of the individual patient's overall risks. PHARMACOLOGY: _Mechanism of Action:_ Etoricoxib is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities in animal models. Etoricoxib is a potent, orally active, highly selective cyclooxygenase-2 (COX-2) inhibitor within and above the clinical dose range. Two isoforms of cyclooxygenase have been identified: cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). COX-1 is responsible for prostaglandin-mediated normal physiologic functions such as gastric cytoprotection and platelet aggregation. Inhibition of COX-1 by nonselective NSAIDs has been associated with gastric damage and platelet inhibition. COX-2 has been shown to be primarily responsible for the synthesis of prostanoid mediators of pain, inflammation, and fever. Selective inhibition of COX-2 by etoricoxib decreases these clinical signs and symptoms with decreased GI toxicity and without effects on platelet function. _Pharmacokinetics:_ _Absorption:_ In studies specifically designated to measure the onset of action of etoricoxib, the onset of action occurred as early as 24 minutes after dosing. Orally administered etoricoxib is well a Read the complete document