BIMECTIN POUR-ON- ivermectin solution

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

Ivermectin (UNII: 8883YP2R6D) (Ivermectin - UNII:8883YP2R6D)

Available from:

Bimeda, Inc.

INN (International Name):

Ivermectin

Composition:

Ivermectin 5 mg in 20 L

Administration route:

TOPICAL

Prescription type:

OTC

Therapeutic indications:

INDICATIONS Bimectin® (ivermectin topical solution) Pour-On applied at the recommended dose level of 500 mcg/kg is indicated for the effective treatment and control of these parasites. Gastrointestinal Roundworms Ostertagia ostertagi             (including inhibited stage)                                 (adults and L4 ) Haemonchus placei          (adults and L4 ) Trichostrongylus axei         (adults and L4 ) T. colubriformis  (adults and L4 ) Cooperia oncophora        (adults and L4 ) Cooperia punctata (adults and L4 ) Cooperia surnabada        (adults and L4 ) Strongyloides papillosus  (adults) Oesophagostomum radiatum (adults and L4 ) Trichuris spp.      (adults) Lung Worms Dictyocaulus viviparus    (adults and L4 ) Cattle Grubs (parasitic stages) Hypoderma bovis H. lineatum Mites Sarcoptes scabiei  var. bovis Lice Linognathus vituli Haematopinus eurysternus Damalinia bovis Solenopotes capillatus Horn Flies Haematobia irritans PERSISTENT ACTIVITY Ivermectin topical solution has been proved to effectivel

Product summary:

HOW SUPPLIED Bimectin® (ivermectin topical solution) Pour-On is available in a 33.8 fl oz/1 Liter Bottle with a measure-squeeze-pour system, an 84.5 fl oz/2.5 Liter Pack, a 169 fl oz/5 Liter Pack, a 338 fl oz/10 Liter Bottle and a 676 fl oz/20 Liter Bottle intended for use with appropriate automatic dosing equipment.

Authorization status:

Abbreviated New Animal Drug Application

Summary of Product characteristics

BIMECTIN POUR-ON- IVERMECTIN SOLUTION
BIMEDA, INC.
----------
BIMEDA, INC. BIMECTIN POUR-ON FOR CATTLE (IVERMECTIN TOPICAL SOLUTION)
ANADA
200-318, APPROVED BY FDA
BIMECTIN
(IVERMECTIN TOPICAL SOLUTION)
POUR-ON FOR CATTLE
APPROVED BY FDA UNDER ANADA # 200-318
CONTAINS 5 MG IVERMECTIN/ML
PARASITICIDE
CONSULT YOUR VETERINARIAN FOR ASSISTANCE IN THE DIAGNOSIS, TREATMENT
AND
CONTROL OF PARASITISM.
INTRODUCTION
Bimectin (ivermectin topical solution) Pour-On delivers internal and
external parasite
control in one convenient low-volume application. Bimectin (ivermectin
topical solution)
Pour-On contains ivermectin, a unique chemical entity.
MODE OF ACTION
Ivermectin is a member of the macrocyclic lactone class of
endectocides which have a
unique mode of action. Compounds of the class bind selectively and
with high affinity to
glutamate-gated chloride ion channels which occur in invertebrate
nerve and muscle
cells. This leads to an increase in the permeability of the cell
membrane to chloride ions
with hyperpolarization of the nerve or muscle cell, resulting in
paralysis and death of the
parasite. Compounds of this class may also interact with other
ligand-gated chloride
channels, such as those gated by the neurotransmitter
gamma-aminobutyric acid
(GABA). The margin of safety for compounds of this class is
attributable to the fact that
mammals do not have the glutamate-gated chloride channels, the
macrocyclic lactones
have a low affinity for other mammalian ligand-gated chloride channels
and they do not
readily cross the blood-brain barrier.
INDICATIONS
Bimectin (ivermectin topical solution) Pour-On applied at the
recommended dose level
of 500 mcg/kg is indicated for the effective treatment and control of
these parasites.
GASTROINTESTINAL ROUNDWORMS
_Ostertagia ostertagi_
(including inhibited stage)
(adults and L )
_Haemonchus placei _
(adults and L )
_Trichostrongylus axei _
(adults and L )
_T. colubriformis _
(adults and L )
_Cooperia oncophora _
(adults and L )
_Cooperia punctata_
(adults and L )
_Cooperia surnabada _