CENTRAGARD- eprinomectin and praziquantel solution

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

EPRINOMECTIN (UNII: 75KP30FD8O) (EPRINOMECTIN - UNII:75KP30FD8O), PRAZIQUANTEL (UNII: 6490C9U457) (PRAZIQUANTEL - UNII:6490C9U457)

Available from:

Merial, Inc.

Administration route:

TRANSDERMAL

Prescription type:

PRESCRIPTION

Therapeutic indications:

CENTRAGARD is indicated for the prevention of heartworm disease caused by Dirofilaria immitis , and for the treatment and control of roundworms (adult and fourth stage larval Toxocara cati ), hookworms (adult and fourth stage larval Ancylostoma tubaeforme ; adult Ancylostoma braziliense ), and tapeworms (adult Dipylidium caninum and Echinococcus multilocularis ) in cats and kittens 7 weeks of age and older and 1.8 lbs or greater.

Product summary:

CENTRAGARD is packaged as a single dose in 0.3 mL (for cats 1.8 – 5.5 lb) and 0.9 mL (for cats 5.6-16.5 lb) applicators. Each size applicator is available in cartons containing 1, 3 or 6 applications. NADA 141-492, Approved by FDA Manufactured for: Merial, Inc. Duluth, GA 30096-4640 USA Made in France CENTRAGARD™ is a trademark of Merial © 2017 Merial. All rights reserved. Revision date: Feb 2018

Authorization status:

New Animal Drug Application

Summary of Product characteristics

CENTRAGARD- EPRINOMECTIN AND PRAZIQUANTEL SOLUTION
MERIAL, INC.
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CENTRAGARD™
(EPRINOMECTIN AND PRAZIQUANTEL TRANSDERMAL SOLUTION)
FOR CATS
CAUTION
Federal (USA) law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION
CENTRAGARD is a transdermal solution containing eprinomectin and
praziquantel available in 0.3 mL
and 0.9 mL unit applicators to treat cats from 1.8 lbs to 33 lbs. Each
mL of CENTRAGARD contains 4
mg of eprinomectin and 83 mg of praziquantel, as well as the inactive
ingredients (dimethyl isosorbide,
glycerol formal, and butylated hydroxytoluene). Eprinomectin belongs
to the avermectin class of
anthelmintics and is a mixture of homologous components referred to as
eprinomectin B1a and B1b.
Praziquantel is a pyrazinoisoquinoline anthelmintic.
INDICATIONS
CENTRAGARD is indicated for the prevention of heartworm disease caused
by _Dirofilaria immitis_, and
for the treatment and control of roundworms (adult and fourth stage
larval _Toxocara cati_), hookworms
(adult and fourth stage larval _Ancylostoma tubaeforme_; adult
_Ancylostoma braziliense_), and tapeworms
(adult _Dipylidium caninum_ and _Echinococcus multilocularis_) in cats
and kittens 7 weeks of age and older
and 1.8 lbs or greater.
DOSAGE AND ADMINISTRATION
CENTRAGARD is dosed at a minimum of 0.055 mL/lb (0.12 mL/kg), which
delivers a minimum dose of
0.23 mg/lb eprinomectin and 4.55 mg/lb praziquantel. Administer the
entire contents of a
CENTRAGARD unit applicator topically once a month as specified in the
following table:
CAT WEIGHT (LB)
VOLUME (ML)
EPRINOMECTIN
(MG)
PRAZIQUANTEL
(MG)
1.8-5.5
0.3
1.2
24.9
5.6-16.5
0.9
3.6
74.7
16.6-22.0
0.3 + 0.9
4.8
99.6
22.1-33.0
0.9 + 0.9
7.2
149.4
To apply CENTRAGARD pull back the plunger of the unit applicator
slightly and remove the cap. Part
the hair in one spot on the midline of the neck between the base of
the skull and the shoulder blades,
place the tip of the unit applicator on the skin and apply the
contents directly on the skin. If the weight of
the cat r