CENTRAGARD- eprinomectin and praziquantel solution

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

EPRINOMECTIN (UNII: 75KP30FD8O) (EPRINOMECTIN - UNII:75KP30FD8O), PRAZIQUANTEL (UNII: 6490C9U457) (PRAZIQUANTEL - UNII:6490C9U457)

Available from:

Boehringer Ingelheim Animal Health USA Inc.

Administration route:

TRANSDERMAL

Prescription type:

PRESCRIPTION

Therapeutic indications:

CENTRAGARD is indicated for the prevention of heartworm disease caused by Dirofilaria immitis , and for the treatment and control of roundworms (adult and fourth stage larval Toxocara cati ), hookworms (adult and fourth stage larval Ancylostoma tubaeforme ; adult Ancylostoma braziliense ), and tapeworms (adult Dipylidium caninum and Echinococcus multilocularis ) in cats and kittens 7 weeks of age and older and 1.8 lbs or greater.

Product summary:

CENTRAGARD is packaged as a single dose in 0.3 mL (for cats 1.8 – 5.5 lb) and 0.9 mL (for cats 5.6-16.5 lb) applicators. Each size applicator is available in cartons containing 1, 3 or 6 applications. Approved by FDA under NADA # 141-492 Manufactured for: Boehringer Ingelheim Animal Health USA Inc. Duluth, GA 30096 Made in France CENTRAGARD™ is a trademark of Boehringer Ingelheim Animal Health USA Inc. © 2019 Boehringer Ingeheim Animal Health USA Inc. All rights reserved. Revision date: Dec 2018

Authorization status:

New Animal Drug Application

Summary of Product characteristics

CENTRAGARD- EPRINOMECTIN AND PRAZIQUANTEL SOLUTION
BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.
----------
CENTRAGARD™
(EPRINOMECTIN AND PRAZIQUANTEL TRANSDERMAL SOLUTION)
FOR CATS
CAUTION
Federal (USA) law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION
CENTRAGARD is a transdermal solution containing eprinomectin and
praziquantel
available in 0.3 mL and 0.9 mL unit applicators to treat cats from 1.8
lbs to 33 lbs. Each
mL of CENTRAGARD contains 4 mg of eprinomectin and 83 mg of
praziquantel, as well
as the inactive ingredients (dimethyl isosorbide, glycerol formal, and
butylated
hydroxytoluene). Eprinomectin belongs to the avermectin class of
anthelmintics and is a
mixture of homologous components referred to as eprinomectin B1a and
B1b.
Praziquantel is a pyrazinoisoquinoline anthelmintic.
INDICATIONS
CENTRAGARD is indicated for the prevention of heartworm disease caused
by _Dirofilaria_
_immitis_, and for the treatment and control of roundworms (adult and
fourth stage larval
_Toxocara cati_), hookworms (adult and fourth stage larval
_Ancylostoma tubaeforme_;
adult _Ancylostoma braziliense_), and tapeworms (adult _Dipylidium
caninum_ and
_Echinococcus multilocularis_) in cats and kittens 7 weeks of age and
older and 1.8 lbs or
greater.
DOSAGE AND ADMINISTRATION
CENTRAGARD is dosed at a minimum of 0.055 mL/lb (0.12 mL/kg), which
delivers a
minimum dose of 0.23 mg/lb eprinomectin and 4.55 mg/lb praziquantel.
Administer the
entire contents of a CENTRAGARD unit applicator topically once a month
as specified in
the following table:
CAT WEIGHT
(LB)
VOLUME (ML) EPRINOMECTIN
(MG)
PRAZIQUANTEL
(MG)
1.8-5.5
0.3
1.2
24.9
5.6-16.5
0.9
3.6
74.7
16.6-22.0
0.3 + 0.9
4.8
99.6
22.1-33.0
0.9 + 0.9
7.2
149.4
To apply CENTRAGARD pull back the plunger of the unit applicator
slightly and remove
the cap. Part the hair in one spot on the midline of the neck between
the base of the
skull and the shoulder blades, place the tip of the unit applicator on
the skin and apply
the contents directly on the