CHLOROQUINE TABLETS 250 mg

Country: Singapore

Language: English

Source: HSA (Health Sciences Authority)

Active ingredient:

CHLOROQUINE PHOSPHATE

Available from:

BEACONS PHARMACEUTICALS PTE. LTD.

ATC code:

P01BA01

Dosage:

250 mg

Pharmaceutical form:

TABLET, FILM COATED

Composition:

CHLOROQUINE PHOSPHATE 250 mg

Administration route:

ORAL

Prescription type:

Pharmacy Only

Manufactured by:

BEACONS PHARMACEUTICALS PTE. LTD.

Authorization status:

ACTIVE

Authorization date:

1988-05-26

Summary of Product characteristics

CHLOROQUINE
TABLETS 250MG
ACTIVE INGREDIENT AND STRENGTH:
Chloroquine Phosphate B.P.
250mg / tablet
THERAPEUTIC PROPERTIES:
Chloroquine is used for the suppression and treatment of malaria. It
is especially active against the erythrocytic forms of malaria
parasites. It is not active against tissue forms of the malaria
parasites.
DOSAGE:
Suppression in adults: 500mg (300mg base) on the same day each week,
beginning 2 weeks prior to exposure, continued for 4 - 8
weeks after leaving the area. If treatment begins on exposure, a
loading dose of 1 gm can be taken in divided doses 6 hours apart.
Suppression in children: 5mg base/kg/week. The loading dose is 10mg
base/kg/week._ _
Acute attacks in adults: an initial dose of 1 gm (600mg base),
followed by 500mg (300mg base) after 6 to 8 hours and a single
dose of 500mg (300mg base) on each of 2 consecutive days.
For children: A total of 25mg / kg is given over 3 days. First dose :
10mg base /_ _kg
Second dose : 5mg base/kg, 6 hours after the first dose
Third dose : 5mg base/kg, 18 hours after the second dose
Fourth Dose : 5mg base/kg, 24 hours after the third dose
For a radical cure of vivax and malariae malaria, concomitant therapy
with an 8-aminoquinoline compound like primaquine is
necessary.
ADVERSE EFFECTS:
In therapeutic doses of chloroquine, mild headache, pruritus,
gastrointestinal complaints, and psychic stimulation have been
observed. Blurring of vision or difficulties in accommodation may also
be observed. Rarely hypotension and EGG changes have
been noted on prolonged therapy, hearing loss and tinnitus, corneal
changes, neuromyopathy, blood dyscrasias and skin effects
have been noted. It may precipitate psoriasis in patients with
psoriasis or porphyria. Hypoglycaemia may be observed in certain
patients.
Psychiatric disorders
− Very common: insomnia
− Common: depression
− Rare: psychiatric disorders such as anxiety, agitation, confusion,
hallucinations, delirium
− Not known: suicidal behaviour, psychosis, aggression, delusion,
paranoia, mania, attention