Clomid

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Clomiphene citrate

Patient Information leaflet

CLOMID
®

(CLO(H)-MID)
_clomiphene citrate (clom-i-feen sit-rate)_
CONSUMER MEDICINE INFORMATION (CMI)

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Clomid.
It does not contain all the available
information.
It does not take the place of talking to
your doctor.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking Clomid
against the benefits he/she expects it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT CLOMID IS USED
FOR
About 20% of couples who
experience difficulty in conceiving,
do so because the woman's ovaries
are not producing and releasing an
egg each menstrual cycle
(anovulation). Your doctor has
prescribed Clomid to treat this.
Clomid acts by causing a gland in the
brain (the anterior pituitary) to
release hormones which stimulate
ovulation.
It must be remembered that there are
many causes of anovulation, so
Clomid may not be effective in all
cases.
When taking Clomid there should be
28-32 days from the beginning of one
period to the next. Your ovaries
should release an egg 6-12 days after
a course of Clomid. You should have
intercourse around this time to
maximise your chances of
conception.
If your period does not arrive after
the 35th day there are two likely
possibilities:
•
the dose of Clomid has not been
sufficient to produce ovulation,
or
•
you are pregnant
If your period is overdue, contact
your doctor/fertility unit and they
will advise you what steps to take.
This medicine is available only with
a doctor's prescription.
BEFORE YOU TAKE
CLOMID
Your doctor will perform a pelvic
examination on you before you begin
to take Clomid. This is to check that
you have no physical conditions
which may stop you falling pregnant
or which might indicate that Clomid
is not a suitable drug for you.
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE CLOMID IF YOU HAVE AN
ALLERGY TO CLOMID OR ANY OF THE
INGREDIENTS

Summary of Product characteristics

 
Clomid 
CCDSv4 PIv6 27 Aug 13            

1 
PRODUCT INFORMATION 
CLOMID™ 
NAME OF THE MEDICINE  

NON-PROPRIETARY NAME  
Clomiphene citrate 
CHEMICAL STRUCTURE  
Clomid  is  clomiphene  citrate,  a  triarylethylene  compound  (related  to  chlorotrianisene  and 
triparanol). 
2-[4
–(2–chloro–1,2–diphenylethenyl)phenoxyl]–N,N–diethylethanamine 
2
–hydroxy–1,2,3- 
propanetricarboxylate  (1:1)  or  2
–[p–(2–chloro–1,2–diphenylvinyl)  phenoxy]  triethylamine 
citrate (1:1). 
The empirical formula is C
26
H
28
CINO,C
6
H
8
O
7
 (MW = 598.09).  
The structural formula appears below: 

DESCRIPTION 
Clomiphene citrate is a white to pale yellow powder. 
Each Clomid tablet contains clomiphene citrate (50 mg), sucrose, lactose, maize starch and 
magnesium stearate.  
PHARMACOLOGY 
The ovulatory response to cyclic Clomid therapy appears to be mediated through increased 
output  of  pituitary  gonadotrophins,  which  in  turn  stimulates  the  maturation  and  endocrine 
activity  of  the  ovarian  follicle  and  the  subsequent  development  and  function  of  the  corpus 
luteum. The role of the pituitary is indicated
by increased urinary excretion of gonadotrophins 
and the response of the ovary, as
manifested by increased urinary oestrogen excretion. 
Ovulation  most  often  occurs  from  6-12  days  after  a  course  of  Clomid.  With  this  in  mind, 
coitus should be timed to coincide with
the expected time of ovulation. 
Although  there  is  no  evidence  of  a  "carry  over  effect"  of  Clomid,  spontaneous  ovulatory 
menses have been noted after Clomid therapy in some patients. 
Infertile  patients  with  the  polycystic  ovary  syndrome  who  have