CYPROSTAT-100

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Cyproterone acetate

Available from:

Bayer Australia Ltd

Class:

Medicine Registered

Patient Information leaflet

 
1209 CYPROSTAT
®
-100 CMI 

Page 1 of 4 
CYPROSTAT
®
-100 
(SIGH·PRO·STAT)

_cyproterone acetate  _

CONSUMER MEDICINE INFORMATION 

WHAT IS IN THIS 
LEAFLET 
This leaflet answers some 
common questions about 
Cyprostat-100. 

It does not contain all the 
available information. It does not 
take the place of talking to your 
doctor or pharmacist. 

All medicines have risks and 
benefits. Your doctor has 
weighed the risks of you taking 
Cyprostat-100 against the benefits 
they expect it will have for you. 

IF YOU HAVE ANY CONCERNS ABOUT 
TAKING THIS MEDICINE, ASK YOUR 
DOCTOR OR PHARMACIST. 

KEEP THIS LEAFLET WITH THE 
MEDICINE. 
You may need to read it again. 
WHAT CYPROSTAT-
100 IS USED FOR 
Cyprostat-100 is an anti-androgen 
medicine. Androgens such as 
testosterone are natural male sex 
hormones. In some types of 
prostate cancer, androgens may 
help the cancer cells to grow. By 
blocking these hormones, 
Cyprostat-100 may slow or stop 
the growth of cancer. 

Cyprostat-100 may be used in 
combination with other medicines 
or following surgical removal of 
the testes to treat side effects such 
as “hot flushes” or “sweats” and 
to prevent any initial worsening 
of the disease. 

ASK YOUR DOCTOR IF YOU HAVE ANY 
QUESTIONS ABOUT WHY THIS 
MEDICINE HAS BEEN PRESCRIBED 
FOR YOU. 
Your doctor may have prescribed 
it for another reason.  

This medicine is available only 
with a doctor’s prescription. 
BEFORE YOU TAKE 
CYPROSTAT-100 
_WHEN YOU MUST NOT TAKE IT _
DO NOT TAKE CYPROSTAT-100 IF 
YOU HAVE AN ALLERGY TO: 
•  cyproterone acetate, the 
active ingredient in 
Cyprostat-100 
•  any of the ingredients listed at 
the end of this leaflet 
_ _
Some of the symptoms of an 
allergic reaction may include: 
•  shortness of breath 
•  wheezing or d

Summary of Product characteristics

 
101109 CYPROSTAT-100 PI                              

                    Page 1 of 9 
CYPROSTAT
®
 100MG PRODUCT INFORMATION 

NAME OF THE MEDICINE 

Cyprostat 100mg 

Each pack contains tablets with 100mg cyproterone acetate. 

Cyproterone acetate: 

CH
3
CH
3
H
H
H
O
O
CH
3
O
Cl
O

Chemical Name: 
6-chloro-17
α hydroxy-1α,2α-methylene-pregna-4,6-diene-3,20-dione 
actetate 
Molecular Formula: 
C
24
H
29
CIO
4

Molecular Mass: 
416.96 
CAS No.: 
427-51-0 

DESCRIPTION 

Cyproterone acetate is a white to pale
yellow crystalline powder. M.P. 206-213
°C. 
Cyproterone acetate is very soluble in chloroform and dioxane,
freely soluble in 
acetone and benzene, soluble in ethanol, methanol and ethyl
acetate, sparingly 
soluble in solvent hexane, and almost insoluble in water. 

PHARMACOLOGY 

Cyprostat is an antiandrogenic hormone preparation.   

Cyproterone acetate inhibits competitively the effect of androgens
at androgen-
dependent target organs, e.g. it shields the prostate from the
effect of androgens 
originating from the gonads and/or the adrenal cortex. Prostatic
carcinoma and its 
metastases are in general androgen-dependent, cyproterone acetate
therefore 
exerts a direct antiandrogenic action on the tumour and its
metastases.  

Cyproterone acetate in addition has a
progestogenic action exerting a negative 
feedback effect centrally on the hypothalamic receptors, so
leading to a reduction in 
gonadotropin release, and hence to diminished production of
testicular androgens. 
Treatment with cyproterone acetate in men results in a reduction
of sexual drive and 
potency and inhibition of gonadal function. These changes are
reversible following 
discontinuation of the therapy. 

The antigonadotropic effect of cyproterone acetate is also exerted
when the 
substance is combined with LHRH agonists. The initi