Country: South Africa
Language: English
Source: South African Health Products Regulatory Authority (SAHPRA)
Lennon
DOXYCYL CAPSULES SCHEDULING STATUS: S4 PROPRIETARY NAME (and dosage form): DOXYCYL CAPSULES COMPOSITION: Each capsule contains: Doxycycline hydrochloride equivalent to doxycycline 50 mg. PHARMACOLOGICAL CLASSIFICATION: A.20.1.1 Broad and medium spectrum antibiotics PHARMACOLOGICAL ACTION: Doxycycline hydrochloride is a tetracycline which is a broad-spectrum antibiotic. It is bacteriostatic against susceptible strains of a wide range of gram-positive and gram-negative organisms. Doxycycline is well absorbed. Absorption is diminished by the presence of iron, aluminium, calcium and magnesium. Doxycycline is widely distributed into pleural and peritoneal fluid, saliva, semen and prostatic fluid. It passes the placental barrier readily and is also present in the milk of lactating patients. It is concentrated by the liver and excreted, by way of the bile, into the intestine from which it is partially reabsorbed. It is clear that with conventional doses doxycycline is not excreted in the urine to the same extent as the other tetracyclines and it does not accumulate in the blood of the patients with renal failure. It also has less impact on the intestinal microflora. INDICATIONS: Doxycycline is indicated in the treatment of acne . CONTRA-INDICATIONS: Doxycycline should not be used in pregnancy. When administered to women during the latter half of pregnancy, to nursing mothers or during childhood up to the age of 12 years, permanent discoloration of the child's teeth may occur. Doxycycline should not be given to patients with a known sensitivity to tetracyclines. Should be avoided in patients with systemic lupus erythematosus. Potentially hepatotoxic drugs should not be given with doxycycline. WARNING: KEEP OUT OF REACH OF CHILDREN. DOSAGE AND DIRECTIONS FOR USE: 50 mg (1 capsule) daily Read the complete document