DRONTAL PLUS TASTE TABS- praziquantel, pyrantel pamoate, febantel tablet, chewable

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

PRAZIQUANTEL (UNII: 6490C9U457) (PRAZIQUANTEL - UNII:6490C9U457), PYRANTEL PAMOATE (UNII: 81BK194Z5M) (PYRANTEL - UNII:4QIH0N49E7), FEBANTEL (UNII: S75C401OS1) (FEBANTEL - UNII:S75C401OS1)

Available from:

Elanco US Inc.

Administration route:

ORAL

Prescription type:

PRESCRIPTION

Therapeutic indications:

Drontal Plus (praziquantel/pyrantel pamoate/febantel) Taste Tabs Broad Spectrum Chewable Anthelmintic Tablets are indicated for removal of Tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus, and removal and control of Echinococcus multilocularis) and for removal of Hookworms (Ancylostoma caninum, Uncinaria stenocephala), Ascarids (Toxocara canis, Toxascaris leonina), and Whipworms (Trichuris vulpis) in dogs. DO NOT USE IN PREGNANT ANIMALS. Dogs treated with elevated levels (6 consecutive days with 3 times the labeled dosage rate) of the combination of febantel and praziquantel in early pregnancy demonstrated an increased incidence of abortion and fetal abnormalities.8 The effects of Drontal Plus Anthelmintic Tablets on pregnant animals have not been determined. There are no known contraindications against the use of praziquantel or pyrantel pamoate in dogs.

Product summary:

Drontal Plus Taste Tabs Tablets are available in three tablet sizes: 40 tabs/box for Puppies and Small Dogs 40 tabs/box for Medium Sized Dogs 30 tabs /box for Large Dogs

Authorization status:

New Animal Drug Application

Summary of Product characteristics

DRONTAL PLUS TASTE TABS- PRAZIQUANTEL, PYRANTEL PAMOATE, FEBANTEL
TABLET,
CHEWABLE
ELANCO US INC.
----------
_ELANCO_ DRONTAL PLUS
(PRAZIQUANTEL/PYRANTEL PAMOATE/FEBANTEL)
TASTE TABS
BROAD SPECTRUM CHEWABLE ANTHELMINTIC TABLETS FOR DOGS
90208174_PA600238X
CAUTION: Federal (U.S.A.) law restricts this drug to use by or on the
order of a
licensed veterinarian.
DESCRIPTION:
Drontal Plus Taste Tabs (praziquantel/pyrantel pamoate/febantel) Broad
Spectrum
Chewable Anthelmintic Tablets for Dogs are available in three tablet
sizes. Each size is
scored for convenient oral administration.
Each Drontal Plus Taste Tabs Tablet for Puppies and Small Dogs
contains 22.7 mg
praziquantel, 22.7 mg pyrantel base as pyrantel pamoate and 113.4 mg
febantel.
Each Drontal Plus Taste Tabs Tablet for Medium Sized Dogs contains
68.0 mg
praziquantel, 68.0 mg pyrantel base as pyrantel pamoate and 340.2 mg
febantel.
Each Drontal Plus Taste Tabs Tablet for Large Dogs contains 136.0 mg
praziquantel,
136.0 mg pyrantel base as pyrantel pamoate, and 680.4 mg febantel.
ACTION:
Drontal Plus Taste Tabs Tablets contain three active ingredients
having different modes
of action and spectra of activity. Praziquantel is active against
cestodes (tapeworms).
Praziquantel is absorbed, metabolized in the liver and excreted in the
bile. Upon entering
the digestive tract from the bile, cestocidal activity is exhibited.
Following exposure to
praziquantel, the tapeworm loses its ability to resist digestion by
the mammalian host.
Because of this, whole tapeworms, including the scolices, are very
rarely passed after
administration of praziquantel. In many instances only disintegrated
and partially
digested pieces of tapeworms will be seen in the stool. The majority
of tapeworms are
digested and are not found in the feces.
Pyrantel pamoate is active against hookworms and ascarids. Pyrantel
pamoate acts on
the cholinergic receptors of the nematode resulting in spastic
paralysis. Peristaltic action
of the intestinal tract then eliminates the parasite.
Febantel is active