Country: United States
Language: English
Source: NLM (National Library of Medicine)
Ephedrine Sulfate (UNII: U6X61U5ZEG) (Ephedrine - UNII:GN83C131XS)
Akorn
Ephedrine Sulfate
Ephedrine Sulfate 50 mg in 1 mL
INTRAMUSCULAR
PRESCRIPTION DRUG
Ephedrine Sulfate Injection, USP is indicated in the treatment of allergic disorders, such as bronchial asthma The drug has long been used as a pressor agent, particularly during spinal anesthesia when hypotension frequently occurs. In Stokes-Adams syndrome with complete heart block, ephedrine has a value similar to that of epinephrine. It is indicated as a central nervous system stimulant in narcolepsy and depressive states. It is also used in myasthenia gravis. Allergic reactions to ephedrine sulfate are rare. The hypersensitivity, if known, is a specific contraindication. Patients hypersensitive to other sympathomimetics may also be hypersensitive to ephedrine sulfate. Prolonged abuse of Ephedrine Sulfate Injection, USP can lead to symptoms of paranoid schizophrenia. When this occurs, patients exhibit such physical signs as tachycardia, poor nutrition and hygiene, fever, cold sweat and dilated pupils. Some measure of tolerance may develop with prolonged or excessive use but addiction does not occur. Tempor
Ephedrine Sulfate Injection USP, 50 mg/mL 1 mL ampules in packs of 10, NDC 17478-515-00 STORAGE: Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Protect from light. Akorn Manufactured by: Akorn, Inc. Lake Forest, IL 60045 ES00N Rev. 03/10
unapproved drug other
EPHEDRINE SULFATE- EPHEDRINE SULFATE INJECTION AKORN _Disclaimer: This drug has not been found by FDA to be safe and effective, and this_ _labeling has not been approved by FDA. For further information about unapproved_ _drugs, click here._ ---------- EPHEDRINE SULFATE INJECTION USP, 50 MG/ML For IM, IV or SC Use RX ONLY DESCRIPTION Ephedrine Sulfate Injection, USP is a sterile solution of 50 mg ephedrine sulfate in Water for Injection. Ephedrine occurs as fine, white, odorless crystals or powder and darkens on exposure to light. It is freely soluble in water and sparingly soluble in alcohol. The chemical name of ephedrine sulfate is (C H NO) •H SO benzenemethanol α-[l - (methylamino) ethyl] - sufate (2:1) (salt). Its molecular weight is 428.54. The structural formula is: CLINICAL PHARMACOLOGY Ephedrine sulfate is a potent sympathomimetic that stimulates both α and β receptors and has clinical uses related to both actions. Its peripheral actions, which it owes in part to the release of norepinephrine, simulate responses that are obtained when adrenergic nerves are stimulated. These include an increase in blood pressure, stimulation of heart muscle, constriction of arterioles, relaxation of the smooth muscle of the bronchi and gastrointestinal tract, and dilation of the pupils. In the bladder, relaxation of the detrusor muscle is not prominent, but the tone of the trigone and vesicle sphincter is increased. Ephedrine sulfate also has a potent effect on the CNS. It stimulates the cerebral cortex and subcortical centers, which accounts for its use in narcolepsy. The cardiovascular responses reported in man include moderate tachycardia, unchanged or augmented stroke volume, enhanced cardiac output, variable alterations in peripheral resistance and usually a rise in blood pressure. The action of ephedrine is more prominent on the heart than on the blood vessels. Ephedrine sulfate increases the flow of coronary, cerebral and muscle blood. In patients with myasthenia gravis, administration of Ephedrine Sulfate Inje Read the complete document