EPRINEX POUR-ON FOR CATTLE- eprinomectin solution

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

eprinomectin (UNII: 75KP30FD8O) (eprinomectin - UNII:75KP30FD8O)

Available from:

Merial, Inc.

INN (International Name):

eprinomectin

Composition:

eprinomectin 5 mg in 1 mL

Administration route:

TOPICAL

Prescription type:

OTC

Therapeutic indications:

EPRINEX (eprinomectin) Pour-On is indicated for the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi ), lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy cattle of all ages, including lactating dairy cattle. Applied at the recommended dose volume of 1 mL/10 kg (22 lb) body weight, to achieve a dose level of 500 mcg eprinomectin/kg body weight, EPRINEX Pour-On is indicated for the effective treatment and control of the following parasites. Gastrointestinal Roundworms   Haemonchus placei (adults and L4)   Ostertagia ostertagi (including inhibited L4) (adults and L4)   Trichostrongylus axei (adults and L4)   Trichostrongylus colubriformis (adults and L4)   Trichostrongylus longispicularis (adults only)   Cooperia oncophora (adults and L4)   Cooperia punctata (adults and L4)   Cooperia surnabada (adults and L4)   Nematodirus helvetianus (adults and L4)   Oesophagostomum radiatum (adults and L4)   Bunosto

Product summary:

EPRINEX (eprinomectin) Pour-On for Beef and Dairy Cattle is available in a 250 mL/8.5 fl oz (67641) or 1 L/33.8 fl oz (67643) bottle with a measure-squeeze-pour system, or in a 2.5 L/84.5 fl oz (67645) or 5 L/169 fl oz (67647) collapsible pack or 20 L/676 fl oz (67648) container intended for use with appropriate automatic dosing equipment.

Authorization status:

New Animal Drug Application

Summary of Product characteristics

EPRINEX POUR-ON FOR CATTLE- EPRINOMECTIN SOLUTION
MERIAL, INC.
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EPRINEX
POUR-ON FOR BEEF
AND DAIRY CATTLE
(EPRINOMECTIN)
PARAS ITICIDE
Contains 5 mg eprinomectin/mL
NOT FOR USE IN CALVES TO BE PROCESSED FOR VEAL.
INTRODUCTION
EPRINEX Pour-On delivers effective internal and external parasite
control in one application.
Discovered and developed by scientists from Merck Research
Laboratories, EPRINEX Pour-On
contains eprinomectin, a unique avermectin. Its broad-spectrum
efficacy in a weatherproof formulation,
margin of safety, zero slaughter withdrawal and zero milk discard,
make it a convenient product for
parasite control in beef and dairy cattle, including lactating dairy
cattle.
MODE OF ACTION
Eprinomectin is a member of the macrocyclic lactone class of
endectocides which have a unique mode
of action. Compounds of the class bind selectively and with high
affinity to glutamate-gated chloride
ion channels which occur in invertebrate nerve and muscle cells.
This leads to an increase in the permeability of the cell membrane to
chloride ions with
hyperpolarization of the nerve or muscle cell, resulting in paralysis
and death of the parasite.
Compounds of this class may also interact with other ligand-gated
chloride channels, such as those
gated by the neurotransmitter gamma-aminobutyric acid (GABA).
The margin of safety for compounds of this class is attributable to
the fact that mammals do not have
glutamate-gated chloride channels, the macrocyclic lactones have a low
affinity for other mammalian
ligand-gated chloride channels and they do not readily cross the
blood-brain barrier.
INDICATIONS
EPRINEX (eprinomectin) Pour-On is indicated for the treatment and
control of gastrointestinal
roundworms (including inhibited _Ostertagia ostertagi_), lungworms,
grubs, sucking and biting lice,
chorioptic and sarcoptic mange mites, and horn flies in beef and dairy
cattle of all ages, including
lactating dairy cattle.
Applied at the recommended dose volume of 1 mL/10 kg (22 lb) body
weight, to achieve a dose level of
5