Eprinex Pour-On

Country: New Zealand

Language: English

Source: Ministry for Primary Industries

Active ingredient:

eprinomectin

Available from:

Boehringer Ingelheim Animal Health New Zealand Limited

INN (International Name):

eprinomectin

Composition:

eprinomectin 5 g/litre

Therapeutic area:

Ectoparasiticide

Authorization status:

ACVM Registered

Authorization date:

1997-01-24

Summary of Product characteristics

Product : Eprinex Pour-On
Date: 14 Apr 2022
ACVM No.: A007191
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FOR ANIMAL TREATMENT ONLY
EPRINEX
 POUR-ON
Pour-On for Cattle and Deer
Active Constituent: EPRINOMECTIN 5mg/mL
ECOTOXIC
FOR THE TREATMENT AND CONTROL IN ALL AGES OF BEEF AND DAIRY CATTLE
(INCLUDING LACTATING COWS) OF:
•
Gastrointestinal roundworms (including inhibited immature
_Ostertagia ostertagi_)
•
Lungworms
•
Sucking and biting lice
•
Sarcoptic and chorioptic mites
AND FOR THE TREATMENT AND CONTROL IN ALL AGES OF DEER OF:
•
Gastrointestinal roundworms
•
Lungworms
AND FOR INCREASE OF MILK PRODUCTION IN GRAZING DAIRY COWS, BASED
ON THE NEW ZEALAND STUDIES DESCRIBED BELOW.
PRODUCT DESCRIPTION
EPRINEX Pour-On delivers internal and external parasite control in one
low volume application. EPRINEX Pour-On contains eprinomectin, a
unique chemical entity. Its convenience, broad-spectrum efficacy, zero
milk discard time, and wide margin of safety make it a suitable
product
for parasite control in beef and dairy cattle, including lactating
dairy
cows and in deer.
MODE OF ACTION
Eprinomectin is a member of the avermectin/milbemycin class of
endectocides which have a unique mode of action. Compounds of the
class bind selectively and with high affinity to glutamate-gated
chloride
ion channels which occur in invertebrate nerve and muscle cells. This
leads to an increase in the permeability of the cell membrane to
chloride ions with hyperpolarization of the nerve or muscle cell,
resulting in paralysis and death of the parasite. Compounds of this
class may also interact with other ligand-gated chloride channels,
such
as those gated by the neurotransmitter gamma-aminobutryric acid
(GABA).
The margin of safety for compounds of this class is attributable to
the
fact that mammals do not have glutamate-gated chloride channels; the
avermectin/milbemycin compounds have a low affinity for other
mammalian ligand-gated chloride channels and they do not readily cross
the blood-brain barrier.
Product : Eprinex Pour-On
Date: 14 Apr 2022
ACVM No.: A0