Euvein 500

Country: Singapore

Language: English

Source: HSA (Health Sciences Authority)

Active ingredient:

Micronized Flavonoidic Fraction equivalent to: Diosmin and Hesperidin

Available from:

MEDICELL PHARMACEUTICAL (S) PTE. LTD.

ATC code:

C05CA53

Dosage:

500mg (450mg and 50mg respectively)

Pharmaceutical form:

TABLET

Composition:

Micronized Flavonoidic Fraction equivalent to: Diosmin and Hesperidin 500mg (450mg and 50mg respectively)

Administration route:

ORAL

Prescription type:

General Sale List

Manufactured by:

General Drugs House Co., Ltd.

Authorization status:

ACTIVE

Authorization date:

2006-12-04

Patient Information leaflet

EUVEIN FILM COATED TABLET
Diosmin 450 mg + Hesperidin 50 mg
COMPOSITION
Each film-coated tablets contains 500 mg of
Micronized Flavonoids which is equivalent
to Diosmin 450 mg + Hesperidin 50 mg and
excipients which includes, Sodium Lauryl
Sulfate, Microcrystalline cellulose and
Colloidal Silicon dioxide, Sodium Starch
Glycolate, Magnesium stearate, Talcum,
HPMC E15, Ethylcellulose, Polyethylene
Glycol 6000, Magnesium carbonate,
Titanium Dioxide, Iron Oxide Red, Iron
Oxide Yellow, 30 % Simethicone.
PRESENTATION/PACKAGING
Brown, oval, slightly convex, film coated
tablets in PVC/aluminum blisters. Each box
contains 30 tablets presented in 10 tablets
per blister together with a patient
information leaflet.
PHARMACODYNAMICS
Venotonic and vascular protector.
- Pharmacology
It is active upon the return vascular system
in the following way :
- it reduces venous distensibility and stasis,
- in the microcirculation, it normalises
capillary permeability and increases
capillary resistance.
- Clinical Pharmacology
Double blind controlled studies using
methods by which the effects of the
product on venous haemodynamics could
be demonstrated and quantified have
confirmed the above pharmacological
properties in man.
- Clinical trials
Double-blind placebo-controlled trials have
demonstrated the activity of the drug in
phlebology, in the treatment of chronic
venous sufficiency of the lower limbs (both
functional and organic).
PHARMACOKINETICS
In man, following oral administration of the
substance containing Euvein:
- excretion is mainly faecal, a mean of 14%
of the dose administered is excreted in the
urine.
- the elimination half-life is 11 hours.
- the drug extensively metabolised as
evidence by the presence of various phenol
acids in the urine.
INDICATION
EUVEIN FILM COATED TABLET
is a
phlebotonic that increases the venous tone
and protects the vessels.
- Treatment of symptoms related to
venolymphatic insufficiency (heavy legs,
pain,nocturnal cramps).
- Treatment of functional symptoms related
to acute hemorrhoidal attacks.
DO

Summary of Product characteristics

Euvein 500 Film Coated Tablet
Diosmin 450 mg + Hesperidin 50 mg
Composition
Each film-coated tablets contains 500 mg of
Micronized Flavonoids which is equivalent
to Diosmin 450 mg + Hesperidin 50 mg and
excipients which includes, Sodium Lauryl
Sulfate, Microcrystalline cellulose and
Colloidal Silicon dioxide, Sodium Starch
Glycolate, Magnesium stearate, Talcum,
HPMC E15, Ethylcellulose, Polyethylene
Glycol 6000, Magnesium carbonate,
Titanium Dioxide, Iron Oxide Red, Iron
Oxide Yellow, 30 % Simethicone.
Presentation/Packaging
Brown, oval, slightly convex, film coated
tablets in PVC/aluminum blisters. Each box
contains 30 tablets presented in 10 tablets
per blister together with a patient
information leaflet.
Pharmacodynamics
Venotonic and vascular protector.
- Pharmacology
It is active upon the return vascular system
in the following way :
- it reduces venous distensibility and stasis,
- in the microcirculation, it normalises
capillary permeability and increases
capillary resistance.
- Clinical Pharmacology
Double blind controlled studies using
methods by which the effects of the
product on venous haemodynamics could
be demonstrated and quantified have
confirmed the above pharmacological
properties in man.
- Clinical trials
Double-blind placebo-controlled trials have
demonstrated the activity of the drug in
phlebology, in the treatment of chronic
venous sufficiency of the lower limbs (both
functional and organic).
Pharmacokinetics
In man, following oral administration of the
substance containing Euvein:
- excretion is mainly faecal, a mean of 14%
of the dose administered is excreted in the
urine.
- the elimination half-life is 11 hours.
- the drug extensively metabolised as
evidence by the presence of various phenol
acids in the urine.
Indication
Euvein 500 Film Coated Tablet is a
phlebotonic that increases the venous tone
and protects the vessels.
- Treatment of symptoms related to
venolymphatic insufficiency (heavy legs,
pain,nocturnal cramps).
- Treatment of functional symptoms related
to acute hemorrhoidal att