Country: Singapore
Language: English
Source: HSA (Health Sciences Authority)
CEFALEXIN MONOHYDRATE EQV CEFALEXIN
GOLDPLUS UNIVERSAL PTE LTD
J01DB01
5300mg/ 100ml
POWDER, FOR SUSPENSION
CEFALEXIN MONOHYDRATE EQV CEFALEXIN 5300mg/ 100ml
ORAL
Prescription Only
REMEDICA LTD
ACTIVE
1997-08-18
P18-0039SR250SIN 003294 FELEXIN 250 MG/5 ML PRODUCT NAME Felexin 250 mg/5 ml powder for oral suspension NAME AND STRENGTH OF ACTIVE SUBSTANCE Each 5 ml of oral suspension contains cefalexin monohydrate equivalent to 250 mg cefalexin. PRODUCT DESCRIPTION Powder for oral suspension. White powder that after reconstitution gives an orange, flavoured suspension. PHARMACOLOGICAL PROPERTIES PHARMACODYNAMIC PROPERTIES Pharmacotherapeutic group: Antibacterials for systemic use; Other beta-lactam antibacterials, ATC code: J01DB01 _In vitro_ tests demonstrate that cephalosporins are bactericidal because of their inhibition of cell-wall synthesis. Cefalexin is active against the following micro- organisms _in vitro_ : Beta-haemolytic streptococci Staphylococci, including coagulase-positive, coagulase-negative and penicillinase-producing strains _Streptococcus pneumoniae_ _Escherichia coli_ Klebsiella species Proteus mirabilis _Haemophilus influenzae _ _Branhamella catarrhalis_ Most strains of enterococci ( _Streptococcus faecalis_ ) and a few strains of staphylococci are resistant to cefalexin. It is not active against most strains of _Enterobacter_ species, _Morganella morganii_ and _Pr. _ _vulgaris_ . It has no activity against _Pseudomonas_ or _Herellea_ species or _Acinetobacter calcoaceticus_ . Penicillin-resistant _Streptococcus _ _pneumonia_ is usually cross-resistant to beta-lactam antibiotics. When tested _in vitro_ methods, staphylococci exhibit cross-resistance between cefalexin and methicillin- type antibiotics. PHARMACOKINETIC PROPERTIES Cefalexin is acid stable. Cefalexin is almost completely absorbed from the gastro-intestinal tract, and 75-100% is rapidly excreted in active form in the urine. Absorption is slightly reduced if the drug is administered with food. The half-life is approximately 60 minutes in patients with normal renal function. Haemodialysis and peritoneal dialysis will remove cefalexin from the blood. Peak blood levels are achieved one hour after administration, and therapeutic levels are maint Read the complete document