Country: Israel
Language: English
Source: Ministry of Health
GENTAMICIN AS SULFATE
UDIM, ISRAEL
SOLUTION FOR INJECTION
GENTAMICIN AS SULFATE 50 MG/ML
S.C, I.M
Required
V.M.D. N.V., BELGIUM
Infections caused by micro-organisms susceptible to gentamycin, as occuring in urogenital, respiratory tissues, skin, uterus and gastrointestinal infections in horses, dogs and cats and pigs.
2010-08-31
GENTAVETO-5 PRO INJ COMPOSITION: per ml solution: 50 mg gentamicin base (as sulfate). Spectrum: Gentamicin is an antibiotic belonging to the group of aminiglycosides. It has bactericidal activity against Gram-positive bacteria (including: Pseudomonas spp., Enterobacter spp., E.Coli, Proteus spp., Salmonella spp., Staphylococci,…). Gentamicin may be active against bacteria which are resistant to other aminoglycoside antibiotics (such as streptomycin and kanamycin). After intramuscular administration, maximum serum concentrations are obtained within 30-60 minutes. Gentamicin is mainly excreted by the kidneys, resulting in high concentrations of the active compound in the urine. INDICATIONS: Infections caused by micro-organisms susceptible to gentamicin, as occurring in urogenital, respiratory, tissue, skin, uterus and gastrointestinal infections in horses, dogs, cats and pigs. CONTRAINDICATIONS: Hypersensitivity to aminoglycoside antibiotics, renal dysfunctions, vestibular, ear or visual dysfunctions, combinations with potential nephrotoxic or muscle-paralysing medicines. PRECAUTIONS: The only half of the normal dose must be given to animals with impaired renal functions. The following conditions have been found to contribute to the toxicity of gentamicin in dogs: - Prior renal damage (most commonly found in dogs of advanced age) and dogs infected with heartworm microfilaria. - Hypovolemic dehydration (dehydrated patients should be rehydrated prior to initiating therapy). In dogs where decreased renal function is suspected prior to treatment, BUN or serum creatinine levels may not indicate the degree of kidney impairment. A creatinine clearance determination may be more useful. Monitoring of renal function during treatment is recommended. Although there is not a completely reliable monitoring program for gentamicin toxicity, urinalysis which may indicate toxicity include: - Decreased specific gravity in the absence of fluid therapy. - Appearance in the urine of casts, albumin, glucose or blood in the absence of p Read the complete document