Country: Australia
Language: English
Source: Department of Health (Therapeutic Goods Administration)
indapamide hemihydrate
Sandoz Pty Ltd
indapamide hemihydrate
Registered
Indapamide Sandoz ® 1 INDAPAMIDE SANDOZ ® Indapamide hemihydrate tablets CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Indapamide Sandoz. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risk of you taking this medicine against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. WHAT INDAPAMIDE SANDOZ IS USED FOR YOU HAVE BEEN PRESCRIBED INDAPAMIDE SANDOZ FOR HIGH BLOOD PRESSURE. Indapamide Sandoz contains the active ingredient indapamide hemihydrate which belongs to a group of medicines called chlorosulphamoyl diurectics (a type of “fluid” or “water”. Indapamide Sandoz is available only with a doctor’s prescription. There is no evidence that Indapamide Sandoz is addictive. _WHY INDAPAMIDE SANDOZ IS USED FOR HIGH BLOOD PRESSURE _ Everyone has blood pressure. This pressure helps to circulate blood all around the body. Your blood pressure may be different at different times of the day, depending on how busy or stressed you are. You have high blood pressure (also known as hypertension) which is when your blood pressure stays higher than is needed, even when you are calm and relaxed. If high blood pressure is not treated it can lead to serious health problems. You may feel fine and have no symptoms, but eventually it can cause stroke, heart disease and kidney failure. Indapamide Sandoz helps to lower your blood pressure. Indapamide Sandoz ® 2 ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY THIS MEDICINE HAS BEEN PRESCRIBED FOR YOU. BEFORE YOU TAKE INDAPAMIDE SANDOZ There are some people who should not take Indapamide Sandoz. Please read the lists below. If you think any of these situations apply to you, or you have any questions, please consult your doctor or pharmacist. _WHEN YOU MUST NOT TAKE I Read the complete document
_Product Information _ _ _ _ _ _ _ _ _ _ _ _Page 1 _ _Indapamide Sandoz 2.5mg Tablets _ _10/2017 _ _Sandoz Pty Ltd _ _ _ _Version 01_ PRODUCT INFORMATION INDAPAMIDE SANDOZ ® 2.5 MG TABLETS NAME OF THE MEDICINE _Generic name:_ Indapamide hemihydrate _Chemical name_ : 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoyl benzamide hemihydrate. _Melting point:_ approximately 185°C _ _ _Chemical Structure: _ , ½ H 2 O C 16 H 16 CLN 3 O 3 S, ½ H 2 O CAS: 26 807-65-8 MW: 374.85 DESCRIPTION Indapamide is a non-thiazide indole derivative of chlorosulfonamide. It is a white crystalline lipophilic powder, soluble in methanol, ethanol, acetic acid and ethyl acetate, very slightly soluble in ether, chloroform and benzene and practically insoluble in water. The excipient ingredients in Indapamide Sandoz are lactose monohydrate, maize starch, magnesium stearate, povidone, Opaseal P-2-0300G clear (ethyl acetate, stearic acid, polyvinyl acetate phthalate, purified water, industrial methylated spirit 74 OP), purified talc, calcium carbonate, acacia, titanium dioxide, sucrose and Opaglos 6000P off-white (shellac, industrial methylated spirit 74 OP, beeswax white, carnuba wax). PHARMACOLOGY _MECHANISM OF ACTION _ Indapamide is an oral antihypertensive medicine. The mechanism whereby indapamide exerts its antihypertensive action has not been completely elucidated; both vascular and renal actions have been implicated. At a dose of 2.5mg the renal effects of indapamide are minimal and the antihypertensive effect of indapamide has been attributed to a reduction in vascular reactivity to pressor N Me N H O Cl SO 2 NH 2 _Product Information _ _ _ _ _ _ _ _ _ _ _ _Page 2 _ _Indapamide Sandoz 2.5mg Tablets _ _10/2017 _ _Sandoz Pty Ltd _ _ _ _Version 01_ amines. The finding that indapamide retains its antihypertensive activity in functionally anephric patients lends support to this hypothesis. The renal site of action of indapamide is the proximal segment of the distal tubule. Indapamide appears to have natriuretic properties (sodium and chlori Read the complete document