Country: Australia
Language: English
Source: Department of Health (Therapeutic Goods Administration)
Hydrochlorothiazide,Irbesartan
Amneal Pharma Australia Pty Ltd
Hydrochlorothiazide,Irbesartan
_Doc ID: 108.AN.M.1.0 _ _ _ _ _ _Page 1 _ _ _ _Irbesartan HCTZ AN capsules – Consumer Medicine Information _ _ _ IRBESARTAN HCTZ AN CAPSULES _Irbesartan plus hydrochlorothiazide _ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Irbesartan HCTZ AN. It does not contain all of the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have benefits and risks. Your doctor has weighed the risks of you taking Irbesartan HCTZ AN against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, TALK TO YOUR DOCTOR OR PHARMACIST. Keep this leaflet with your medicine. You may need to read it again. WHAT IRBESARTAN HCTZ AN IS USED FOR Irbesartan HCTZ AN lowers high blood pressure, which doctors call hypertension. Everyone has blood pressure. This pressure helps get your blood all around your body. Your blood pressure may be different at different times of the day, depending on how busy or worried you are. You have hypertension (high blood pressure) which means your blood pressure stays high, even when you are calm and relaxed. There are often no symptoms of high blood pressure. The only way of knowing that you have hypertension is to have your blood pressure checked on a regular basis. If high blood pressure is not treated it can lead to serious health problems, such as stroke, heart disease and kidney failure. HOW IRBESARTAN HCTZ AN WORKS Irbesartan HCTZ AN contains irbesartan and hydrochlorothiazide. Both medicines reduce blood pressure in different ways. Irbesartan belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin-II is a substance produced in the body that causes blood vessels to narrow. Irbesartan blocks angiotensin-II and therefore widens your blood vessels, making it easier for your heart to pump blood throughout your body. This helps to lower your blood pressure. Hydrochlorothiazide belongs to the class of medicines known as diure Read the complete document
_ _ _ _ _Irebesartan HCTZ AN tablets Product Information _ _ _ _Scentia Pharmaceuticals Pty Ltd _ Doc ID: 109.AN.P.1.0 Page 1 IRBESARTAN HCTZ AN 150/12.5, 300/12.5 & 300/25 _IRBESARTAN 150 MG + HYDROCHLOROTHIAZIDE 12.5 MG TABLETS _ _IRBESARTAN 300 MG + HYDROCHLOROTHIAZIDE 12.5 MG TABLETS _ _IRBESARTAN 300 MG + HYDROCHLOROTHIAZIDE 25 MG TABLETS _ _ _ PRODUCT INFORMATION NAME OF THE MEDICINE The name of this medicine is Irbesartan/Hydrochlorothiazide IRBESARTAN: CHEMICAL NAME: 2-butyl-3-[(2'-(1_H_-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,3-diazaspiro [4,4] non-1- en-4-one MOLECULAR FORMULA: C 25 H 28 N 6 O MOLECULAR WEIGHT: 428.5 CAS REGISTRY NUMBER: 1384-11-6 HYDROCHLOROTHIAZIDE: CHEMICAL NAME: 6-chloro-3,4-dihydro-2_H_-1,2,4-benzothiadiazine-7-sulfonamide 1,1- dioxide MOLECULAR FORMULA: C 7 H 8 ClN 3 O 4 S 2 MOLECULAR WEIGHT: 297.7 CAS REGISTRY NUMBER: 58-93-5 DESCRIPTION IRBESARTAN HCTZ AN 150/12.5, IRBESARTAN HCTZ AN 300/12.5 and IRBESARTAN HCTZ AN 30/25 (irbesartan/hydrochlorothiazide) is an oral antihypertensive agent combining a nonpeptide angiotensin II receptor (AT 1 thiazide diuretic, hydrochlorothiazide. _ _ _ _ _Irebesartan HCTZ AN tablets Product Information _ _ _ _Scentia Pharmaceuticals Pty Ltd _ Doc ID: 109.AN.P.1.0 Page 2 Irbesartan is a white or off-white crystalline powder. It is a relatively non-polar compound with a partition coefficient (octanol-water) of 10.1 at a pH of 7.4. Irbesartan is practically insoluble in water, sparingly soluble in methanol, slightly soluble in methylene chloride. Hydrochlorothiazide is a white crystalline powder. It is Very slightly soluble in water, soluble in acetone, sparingly soluble in ethanol (96 percent). It dissolves in dilute solutions of alkali hydroxides. The inactive ingredients in Irbesartan HCTZ tablets include lactose; croscarmellose sodium; povidone, pigment blend PB-24899 (ARPING 107861 consisting of iron oxide red, iron oxide yellow, lactose); magnesium stearate. Irbesartan HCTZ AN 300/12.5mg and Irbesartan HCTZ AN 150/12.5mg tablets contain opadry II Read the complete document