ISOFLURANE inhalant

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

Isoflurane (UNII: CYS9AKD70P) (Isoflurane - UNII:CYS9AKD70P)

Available from:

Patterson Veterinary

INN (International Name):

Isoflurane

Composition:

Isoflurane 1 mL in 1 mL

Administration route:

RESPIRATORY (INHALATION)

Prescription type:

PRESCRIPTION

Therapeutic indications:

Isoflurane, USP is used for induction and maintenance of general anesthesia in horses and dogs. Isoflurane, USP is contraindicated in horses and dogs with known sensitivity to isoflurane or to other halogenated agents.

Product summary:

Isoflurane, USP is packaged in 100mL (NDC 14043-704-05) and 250 mL (NDC 14043-704-06) amber-colored bottles. Storage: Store at room temperature 15° to 30°C (59° to 86° F).

Authorization status:

Abbreviated New Animal Drug Application

Summary of Product characteristics

ISOFLURANE- ISOFLURANE INHALANT
PATTERSON VETERINARY
----------
ISOFLURANE, USP
INHALATION ANESTHETIC FOR USE IN HORSES AND DOGS
WARNING: Not for use in horses intended for food.
CAUTION:
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION
Isoflurane, USP is a nonflammable, nonexplosive general inhalation
anesthetic agent. Its chemical name
is 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether, and its
structural formula is:
Each mL contains 99.9% isoflurane.
*
Some physical constants are:
Molecular weight
184.5
Boiling point at 760 mm Hg
48.5°C
Refractive index n
1.2990-1.3005
Specific gravity 25°/25°C
1.496
Vapor pressure in mm Hg
20°C
238
25°C
295
30°C
367
35°C
450
log
P
=
A + B
T
where:
A = 8.056
B = - 1664.58
T = °C + 273.16
Partition coefficients at 37°C:
Water/gas
0.61
Blood/gas
1.43
Oil/gas
90.8
Partition coefficients at 25°C - rubber and plastic:
Equation for vapor pressure calculation:
20
D
*
10
vap
Conductive rubber/gas
62.0
Butyl rubber/gas
75.0
Polyvinyl chloride/gas
110.0
Polyethylene/gas
~ 2.0
Polyurethane/gas
~ 1.4
Polyolefin/gas
~ 1.1
Butyl acetate/gas
~ 2.5
Purity by gas chromatography
>99.9%
Lower limit of flammability in
oxygen or nitrous oxide at 9
joules/sec. and 23°C
None
Lower limit of flammability in
oxygen or nitrous oxide at 900
joules/sec. and 23°C
Greater than useful concentration
in anesthesia
MAC (Minimum Alveolar Concentration) is 1.31% in horses and 1.28% in
dogs .
Isoflurane is a clear, colorless, stable liquid containing no
additives or chemical stabilizers. Isoflurane
has a mildly pungent, musty, ethereal odor. Samples stored in indirect
sunlight in clear, colorless glass
for five years, as well as samples directly exposed for 30 hours to a
2 amp, 115 volt, 60 cycle long
wave U.V. light were unchanged in composition as determined by gas
chromatography. Isoflurane in
one normal sodium methoxide-methanol solution, a strong base, for over
six months consumed
essentially no alkali, indicative of strong base stability. Isoflu