IVERMECTIN POUR-ON FOR CATTLE- ivermectin solution

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

IVERMECTIN (UNII: 8883YP2R6D) (IVERMECTIN - UNII:8883YP2R6D)

Available from:

Durvet

INN (International Name):

IVERMECTIN

Composition:

IVERMECTIN 5 mg in 1 mL

Administration route:

TOPICAL

Prescription type:

OTC

Therapeutic indications:

Ivermectin Pour-On for Cattle applied at the recommended dose level of 500 mcg/kg is indicated for the effective treatment and control of these parasites. Gastrointestinal Roundworms Ostertagia ostertagi (including inhibited stage)        (adults and L4 ) Haemonchus placei                                                 (adults and L4 ) Trichostrongylus axei                                              (adults and L4 ) T. colubriformis                                                       (adults and L4 ) Cooperia oncophora                                                 (adults and L4 ) Cooperia punctata                                                  (adults and L4 ) Cooperia surnabada                                                 (adults and L4 ) Strongyloides papillosus                                                      (adults) Oesophagostomum radiatum                                  (adults and L4 ) Trichuris spp.                                                                    (adults) Lungworms Dictyocaulus viviparus                                              (adults and L4 ) Cattle Grubs                                                       (parasitic stages) Hypoderma bovis H. lineatum Mites Sarcoptes scabiei var. Bovis Lice Linognathus vituli Haematopinus eurystemus Damalinia bovis Solenopotes capillatus Horn Flies Haematobia irritans PERSISTENT ACTIVITY Ivermectin Pour-On for Cattle has been proved to effectively control infections and to protect cattle from re-infection with: Oesophagostomum radiatum and Dictyocaulus viviparous for 28 days after treatment; Cooperia punctata and Trichostrongylus axei for 21 days after treatment; Ostertagia ostertagi , Haemonchus placei , Cooperia oncophora and Cooperia surnabada for 14 days after treatment; Damalinia bovis for 56 days after treatment. TREATMENT OF CATTLE FOR HORN FLIES Ivermectin Pour-On for Cattle controls horn flies (Haematobia irritans ) for up to 28 days after dosing. For best results Ivermectin Pour-On for Cattle should be part of a parasite control program for both internal and external parasites based on the epidemiology of these parasites. Consult your veterinarian or an entomologist for the most effective timing of applications. Manufactured for: Durvet Inc. Blue Springs, Missouri 64014 www.durvet.com

Product summary:

Ivermectin Pour-On for Cattle is available in 250 mL (8.5 fl oz) and 1 L (33.8 fl oz) tip and measure bottles, and 2.5 L (84.5 fl oz), 5 L (169.0 fl oz), and 5 Gallon (639.0 fl oz) containers for use with an appropriate automatic dosing applicator.

Authorization status:

Abbreviated New Animal Drug Application

Summary of Product characteristics

IVERMECTIN POUR-ON FOR CATTLE- IVERMECTIN SOLUTION
DURVET
----------
IVERMECTIN
(IVERMECTIN TOPICAL SOLUTION)
5 MG IVERMECTIN PER ML
POUR-ON FOR CATTLE POUR-ON FOR CATTLE
PARASITICIDE Kills: Roundworms (including Brown Stomach Worm),
Lungworms,
Grubs, Sucking Lice, Biting Lice, Mange Mites, Horn Flies
WARNING! FLAMMABLE! KEEP AWAY FROM HEAT, SPARKS, OPEN FLAME, AND
OTHER SOURCES OF IGNITION.
Approved by FDA under ANADA # 200-340
Restricted Drug (California) - Use Only as Directed
FOR ANIMAL USE ONLY • KEEP OUT OF REACH OF CHILDREN
WWW.DURVET.COM
See attached booklet for complete indications and use directions.
PARASITICIDE
CONSULT YOUR VETERINARIAN FOR ASSISTANCE IN THE DIAGNOSIS, TREATMENT
AND
CONTROL OF PARASITISM.
INTRODUCTION
Ivermectin Pour-On for Cattle (ivermectin topical solution) delivers
internal and external
parasite control in one convenient low-volume application. Ivermectin
Pour-On for Cattle
contains ivermectin, a unique chemical entity.
MODE OF ACTION
Ivermectin is a member of the macrocylic lactone class of endectocides
which have a
unique mode of action. Compounds of the class bind selectively and
with high affinity to
glutamate-gated chloride ion channels which occur in invertebrate
nerve and muscle
cells.
This leads to an increase in the permeability of the cell membrane to
chloride ions with
hyperpolarization of the nerve or muscle cell, resulting in paralysis
and death of the
parasite.
Compounds of this class may also interact with other ligand-gated
chloride channels,
such as those gated by the neurotransmitter gamma aminobutyric acid
(GABA).
The margin of safety for compounds of this class is attributable to
the fact that
mammals do not have glutamate-gated chloride channels, the macrocyclic
lactones have
a low affinity for other mammalian ligand-gated chloride channels and
they do not readily
a low affinity for other mammalian ligand-gated chloride channels and
they do not readily
cross the blood-brain barrier.
INDICATIONS
Ivermectin Pour-On for Cattle applied at the recommended dose le