IVOMEC- ivermectin injection, solution

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

ivermectin (UNII: 8883YP2R6D) (ivermectin - UNII:8883YP2R6D)

Available from:

Merial, Inc.

INN (International Name):

ivermectin

Composition:

ivermectin 10 mg in 1 mL

Administration route:

SUBCUTANEOUS

Prescription type:

OTC

Therapeutic indications:

IVOMEC Injection is indicated for the effective treatment and control of the following harmful species of gastrointestinal roundworms, lungworms, grubs, sucking lice, and mange mites in cattle: Gastrointestinal Roundworms (adults and fourth-stage larvae): Ostertagia ostertagi (including inhibited O. ostertagi ) O. lyrata Haemonchus placei Trichostrongylus axei T. colubriformis Cooperia oncophora C. punctata C. pectinata Oesophagostomum radiatum Bunostomum phlebotomum Nematodirus helvetianus (adults only) N. spathiger (adults only) Lungworms (adults and fourth-stage larvae): Dictyocaulus viviparus Cattle Grubs (parasitic stages): Hypoderma bovis H. lineatum Sucking Lice: Linognathus vituli Haematopinus eurysternus Solenopotes capillatus Mites (scabies): Psoroptes ovis (syn. P. communis var. bovis ) Sarcoptes scabiei var. bovis IVOMEC Injection has been proved to effectively control infections and to protect cattle from reinfection with Dictyocaulu

Product summary:

IVOMEC Injection for Cattle and Swine is available in four ready-to-use pack sizes: The 50 mL pack is a multiple-dose, rubber-capped bottle. Each bottle contains sufficient solution to treat 10 head of 550 lb (250 kg) cattle or 100 head of 38 lb (17.3 kg) swine. The 200 mL pack is a soft, collapsible pack designed for use with automatic syringe equipment. Each pack contains sufficient solution to treat 40 head of 550 lb (250 kg) cattle or 400 head of 38 lb (17.3 kg) swine. The 500 mL pack is a soft, collapsible pack designed for use with automatic syringe equipment. Each pack contains sufficient solution to treat 100 head of 550 lb (250 kg) cattle or 1000 head of 38 lb (17.3 kg) swine. The 1000 mL is a soft, collapsible pack designed for use with automatic syringe equipment. Each pack contains sufficient solution to treat 200 head of 550 lb (250 kg) cattle or 2000 head of 38 lb (17.3 kg) swine.

Authorization status:

New Animal Drug Application

Summary of Product characteristics

IVOMEC- IVERMECTIN INJECTION, SOLUTION
MERIAL, INC.
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IVOMEC
(IVERMECTIN)
INJECTION FOR CATTLE AND SWINE
NADA 128-409, Approved by the FDA
67306, 67307, 67308, 67309
1% STERILE SOLUTION
A PARASITICIDE FOR THE TREATMENT AND CONTROL OF INTERNAL AND EXTERNAL
PARASITES OF CATTLE AND
SWINE
CONSULT YOUR VETERINARIAN FOR ASSISTANCE IN THE DIAGNOSIS, TREATMENT
AND CONTROL OF PARASITISM.
INTRODUCTION
IVOMEC (ivermectin) is an injectable parasiticide for cattle and
swine. One low-volume dose
effectively treats and controls the following internal and external
parasites that may impair the health of
cattle and swine: gastrointestinal roundworms (including inhibited
_Ostertagia ostertagi_ in cattle),
lungworms, grubs, sucking lice, and mange mites of cattle; and
gastrointestinal roundworms, lungworms,
lice, and mange mites of swine. Discovered and developed by scientists
from Merck Research
Laboratories, ivermectin is a novel chemical entity. Its convenience,
broad-spectrum efficacy, and
safety margin make IVOMEC Injection a unique product for parasite
control of cattle and swine.
PRODUCT DESCRIPTION
Ivermectin is derived from the avermectins, a family of potent,
broad-spectrum antiparasitic agents
isolated from fermentation of _Streptomyces avermitilis_.
IVOMEC Injection is a clear, ready-to-use, sterile solution containing
1% ivermectin, 40% glycerol
formal, and propylene glycol, q.s. ad 100%. IVOMEC Injection is
formulated to deliver the
recommended dose level of 200 mcg ivermectin/kilogram of body weight
in cattle when given
subcutaneously at the rate of 1 mL/110 lb (50 kg). In Swine, IVOMEC
Injection is formulated to deliver
the recommended dose level of 300 mcg ivermectin/kilogram body weight
when given subcutaneously
in the neck at the rate of 1 mL per 75 lb (33 kg).
MODE OF ACTION
Ivermectin is a member of the macrocyclic lactone class of
endectocides which have a unique mode of
action. Compounds of the class bind selectively and with high affinity
to glutamate-gated chloride ion
channels which occur in inver