IVOMEC POUR-ON FOR CATTLE- ivermectin solution

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

ivermectin (UNII: 8883YP2R6D) (ivermectin - UNII:8883YP2R6D)

Available from:

Merial, Inc.

INN (International Name):

ivermectin

Composition:

ivermectin 5 mg in 1 mL

Administration route:

TOPICAL

Prescription type:

OTC

Therapeutic indications:

IVOMEC Pour-On (ivermectin topical solution) applied at the recommended dose level of 500 mcg/kg is indicated for the effective treatment and control of these parasites. Gastrointestinal Roundworms Ostertagia ostertagi (including inhibited stage) (adults and L4) Haemonchus placei (adults and L4) Trichostrongylus axei (adults and L4) T. colubriformis (adults and L4) Cooperia oncophora (adults and L4) Cooperia punctata (adults and L4) Cooperia surnabada (adults and L4) Strongyloides papillosu s (adults) Oesophagostomum radiatum (adults and L4) Trichuris spp. (adults) Lungworms Dictyocaulus viviparus (adults and L4) Cattle Grubs (parasitic stages)   Hypoderma bovis   H. Iineatum Mites   Sarcoptes scabiei var. bovis Lice   Linognathus vituli   Haematopinus eurysternus   Damalinia bovis   Solenopotes capillatus Horn Flies   Haematobia irritans

Product summary:

IVOMEC Pour-On (ivermectin topical solution) is available in an 8.5 fl oz/250 mL bottle or 33.8 fl oz/1 L bottle with a measure-squeeze-pour system, or in an 84.5 fl oz/2.5 L or 169 oz/5 L collapsible pack, or 676 fl oz/20 L container intended for use with appropriate automatic dosing equipment.

Authorization status:

New Animal Drug Application

Summary of Product characteristics

IVOMEC POUR-ON FOR CATTLE- IVERMECTIN SOLUTION
MERIAL, INC.
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IVOMEC POUR-ON
(IVERMECTIN TOPICAL SOLUTION)
FOR CATTLE
NADA 140-841, Approved by the FDA
CONTAINS 5 MG IVERMECTIN/ML
PARAS ITICIDE
Product Numbers: 67650, 67652, 67654, 67656
CONSULT YOUR VETERINARIAN FOR ASSISTANCE IN THE DIAGNOSIS, TREATMENT
AND CONTROL OF PARASITISM.
INTRODUCTION
IVOMEC Pour-On (ivermectin topical solution) delivers internal and
external parasite control in one
convenient low-volume application. Discovered and developed by
scientists from Merck Research
Laboratories, IVOMEC Pour-On (ivermectin topical solution) contains
ivermectin, a unique chemical
entity.
MODE OF ACTION
Ivermectin is a member of the macrocylic lactone class of endectocides
which have a unique mode of
action. Compounds of the class bind selectively and with high affinity
to glutamate-gated chloride ion
channels which occur in invertebrate nerve and muscle cells.
This leads to an increase in the permeability of the cell membrane to
chloride ions with
hyperpolarization of the nerve or muscle cell, resulting in paralysis
and death of the parasite.
Compounds of this class may also interact with other ligand-gated
chloride channels, such as those
gated by the neurotransmitter gamma-aminobutyric acid (GABA).
The margin of safety for compounds of this class is attributable to
the fact that mammals do not have
glutamate-gated chloride channels, the macrocyclic lactones have a low
affinity for other mammalian
ligand-gated chloride channels and they do not readily cross the
blood-brain barrier.
INDICATIONS
IVOMEC Pour-On (ivermectin topical solution) applied at the
recommended dose level of 500 mcg/kg
is indicated for the effective treatment and control of these
parasites.
GASTROINTESTINAL ROUNDWORMS
_Ostertagia ostertagi_ (including inhibited
stage)
(adults and L4)
_Haemonchus placei_
(adults and L4)
_Trichostrongylus axei_
(adults and L4)
_T. colubriformis_
(adults and L4)
_Cooperia oncophora_
(adults and L4)
_Cooperia punctata_
(adults and L4)
_Cooperia surnabad