Jurox GnRH Injection

Country: Australia

Language: English

Source: APVMA (Australian Pesticides and Veterinary Medicines Authority)

Active ingredient:

GONADORELIN ACETATE

Available from:

JUROX PTY LIMITED

Pharmaceutical form:

PARENTERAL LIQUID/SOLUTION/SUSPENSION

Composition:

GONADORELIN ACETATE UNGROUPED Active 50.0 ug/ml

Units in package:

100 mL; 20 mL

Class:

VM - Veterinary Medicine

Therapeutic area:

ENDOCRINE SYSTEM

Product summary:

Poison schedule: 4; Withholding period: MEAT: Zero (0) days; MILK: Zero (0) days . Zero (0) days. Before using this prod uct, confirm the current ESI from Jurox Pty Limited on 1800 023 312 or the APVMA website (www.apvma.gov.au/residues).; Host/pest details: CATTLE: [CYSTIC OVARIES, DELAYED OVULATION, IMPROVEMENT OF POSTPARTUM FERTILITY, SYNCHRONISATION OF OESTRUS]

Authorization status:

Registered

Authorization date:

2023-07-01

Patient Information leaflet

Product Name:
APVMA Approval No:
Jurox GnRH Injection
91092/130917
Label Name:
Jurox GnRH Injection
Signal Headings:
PRESCRIPTION ANIMAL REMEDY
KEEP OUT OF REACH OF CHILDREN
FOR ANIMAL TREATMENT ONLY
Constituent
Statements:
Active constituent: 47.6 μg/mL Gonadorelin (equivalent to 50 μg/mL
Gonadorelin acetate)
Claims:
For use in oestrus synchronisation programs in combination with
PGF2α.
For the treatment of cystic ovaries, prevention of delayed ovulation
and improvement of
postpartum fertility in cattle.
Net Contents:
20 mL
100 mL
Directions for Use:
Restraints:
Contraindications:
Precautions:
Side Effects:
Dosage and
Administration:
Use the contents of the vial within 30 days of first broaching.
Discard the unused portion.
Cattle:
Injection to be given by intramuscular injection into the anterior
half of the neck.
Cystic ovaries: 10 mL equivalent to 500 μg Gonadorelin RLP APPROVED
Prevention of delayed ovulation: 5 mL equivalent to 250 μg
Gonadorelin
Improvement of postpartum fertility: 5 mL equivalent to 250 μg
Gonadorelin
Oestrus synchronisation: 2 mL equivalent to 100 μg Gonadorelin per
dose, for example
(see enclosed leaflet).
Day 0 2 mL Jurox GnRH Injection
Day 7 500 μg Cloprostenol (Juramate Prostaglandin Injection or
Juramate Synthetic
Prostaglandin for Cattle and Horses)
Day 9 2 mL Jurox GnRH Injection
Insemination 8-24 hours after 2nd GnRH
General Directions:
PHARMACOLOGY
Gonadorelin is a synthetic decapeptide, identical to the endogenous
Gonadotrophin
Releasing Hormone (GnRH). GnRH is synthesised and secreted in a
pulsatile manner by
the hypothalamus and is transported via the hypothalamic-hypophyseal
portal circulation to
its site of action, the anterior pituitary.
Actions
Gonadorelin induces the synthesis and release of gonadotrophins from
the anterior
pituitary, such that LH and FSH are released from the pituitary
shortly after gonadorelin
administration. LH and FSH act on the ovary to stimulate maturation of
ovarian follicles and ovulation.
Pharmacokinetics
Gonadorelin is rapidly absorbed